MLS000532223

• 常用名: MLS000532223
• 英文名: MLS000532223
• CAS号: 16616-39-0
• 分子量: 251.23700
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₅H₉NO₃
• 熔点: N/A
• 闪点: N/A

MLS000532223用途

MLS000532223 是一种选择性的,具有高亲和力的 Rho 家族 GTPases (Rho family GTPases) 抑制剂,其 EC50 范围为 16-120 μM。MLS000532223 能阻止 GTP 与几种 GTPases 相结合。小 GTPases 是细胞活性的关键调节因子。

MLS000532223名称

• 中文名: 1-(3-硝基苯基)-3-苯基丙-2-炔-1-酮
• 英文名: 1-(3-nitrophenyl)-3-phenylprop-2-yn-1-one

MLS000532223生物活性

• 描述: MLS000532223 是一种选择性的,具有高亲和力的 Rho 家族 GTPases (Rho family GTPases) 抑制剂,其 EC50 范围为 16-120 μM。MLS000532223 能阻止 GTP 与几种 GTPases 相结合。小 GTPases 是细胞活性的关键调节因子。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 拉斯
• 靶点实验:

  EC50: 16-120 μM (Rho family GTPases)[1]

• 体外研究: MLS000532223以剂量依赖的方式阻止GTP与几种GTP酶结合[1]。MLS000532223调节Rho家族GTP结合动力学[1]。MLS000532223在基于细胞的分析中具有活性,并抑制EGF刺激的Rac 1激活[1]。MLS000532223抑制Rho家族GTPase激活下游的肌动蛋白重排和细胞形态变化[1]。MLS000532223(10μM)调节肥大细胞肌动蛋白重塑[1]。MLS000532223(10μM)抑制RBL细胞配体刺激的β-己糖胺酶分泌[1]。
• 参考文献:

  [1]. Zurab Surviladze, et al. Identification of a Small GTPase Inhibitor Using a High-Throughput Flow Cytometry Bead-Based Multiplex Assay. J Biomol Screen. 2010 Jan;15(1):10-20.

MLS000532223物理化学性质

• 分子式: C₁₅H₉NO₃
• 分子量: 251.23700
• 精确质量: 251.05800
• PSA: 62.89000
• LogP: 3.35240
• InChIKey: JODIUOIVYGKAJH-UHFFFAOYSA-N
• SMILES: O=C(C#Cc1ccccc1)c1cccc([N+](=O)[O-])c1
• 外观性状: 固体
• 储存条件: 2-8°C，密封，干燥

MLS000532223靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Single concentration confirmation of small molecule activators of the apoptotic arm o... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A406-UPR-CHOP-CP-Agonist-Assay

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

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MLS000532223英文别名

• m-Nitrobenzoylphenylacetylen
• 1-(3-nitrophenyl)-3-phenyl-2-propyn-1-one
• 2-Propyn-1-one,1-(3-nitrophenyl)-3-phenyl
• 1-Phenyl-3-(3-nitrophenyl)-1-propin-3-on