IDO-IN-2

• 常用名: IDO-IN-2
• 英文名: IDO-IN-2
• CAS号: 1668565-74-9
• 分子量: 497.63
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₃₅N₇O
• 熔点: N/A
• 闪点: N/A

IDO-IN-2用途

IDO-IN-2是IDO的抑制剂，来自专利WO / 2015031295A1化合物实例1。其在HeLa和HEK293细胞中的IC₅₀值分别为0.068和 0.16μM。

IDO-IN-2名称

• 中文名: IDO-IN-2
• 英文名: IDO-IN-2

IDO-IN-2生物活性

• 描述: IDO-IN-2是IDO的抑制剂,来自专利WO/2015031295A1化合物实例1。其在HeLa和HEK293细胞中的IC50值分别为0.068和 0.16μM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 吲哚胺2,3-二氧化酶(IDO)
  研究领域 >> 癌症
• 靶点实验:

  IDO:68 nM (IC50, in HeLa cell)

  IDO:160 nM (IC50, in HEK293 cell)

IDO-IN-2物理化学性质

• 分子式: C₂₉H₃₅N₇O
• 分子量: 497.63
• InChIKey: CJNMMPAEIYFQIJ-UHFFFAOYSA-N
• SMILES: Cc1ccc(NC(=O)Nc2cc(-c3ccccc3-c3nn[nH]n3)ccc2N(CC(C)C)CC(C)C)cc1
• 外观性状: 粉末
• 储存条件: -20℃
• 水溶解性: DMSO: ≥ 31 mg/mL

IDO-IN-2靶点实验

查看更多实验

实验名称：Stability in human liver microsomes assessed as half life 来源：ChEMBL 靶标：N/A External Id：CHEMBL5259456

实验名称：Transactivation of PXR (unknown origin) relative to control 来源：ChEMBL 靶标：Nuclear receptor subfamily 1 group I member 2 External Id：CHEMBL5259445

实验名称：Transactivation of PXR (unknown origin) 来源：ChEMBL 靶标：Nuclear receptor subfamily 1 group I member 2 External Id：CHEMBL5259441

实验名称：Inhibition of CYP2C9 (unknown origin) 来源：ChEMBL 靶标：Cytochrome P450 2C9 External Id：CHEMBL5259443

实验名称：Metabolic stability in human liver microsomes assessed as compound remaining at 0.5 u... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5259438

实验名称：Inhibition of TDO (unknown origin) expressed in HEK cells 来源：ChEMBL 靶标：Tryptophan 2,3-dioxygenase External Id：CHEMBL5259437

实验名称：Metabolic stability in mouse liver microsomes assessed as compound remaining at 0.5 u... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5259440

实验名称：Metabolic stability in rat liver microsomes assessed as compound remaining at 0.5 uM ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5259439

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：Inhibition of IDO1 (unknown origin) expressed in human HeLa cells 来源：ChEMBL 靶标：Indoleamine 2,3-dioxygenase 1 External Id：CHEMBL5259436

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IDO-IN-2英文别名

• IDO-IN2