GNE-0946

• 常用名: GNE-0946
• 英文名: Gne-0946
• CAS号: 1677667-24-1
• 分子量: 460.79
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₁₂ClF₃N₂O₄
• 熔点: N/A
• 闪点: N/A

GNE-0946用途

GNE-0946 是一个有效且有选择性的 RORγ(RORc) 拮抗剂,对 HEK-293 细胞的 EC50 值为 4 nM.

GNE-0946名称

• 中文名: GNE-0946
• 英文名: GNE-0946

GNE-0946生物活性

• 描述: GNE-0946 是一个有效且有选择性的 RORγ(RORc) 拮抗剂,对 HEK-293 细胞的 EC50 值为 4 nM.
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> ROR
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Fauber BP, et al. Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists. Bioorg Med Chem Lett. 2015 Aug 1;25(15):2907-12.

GNE-0946物理化学性质

• 分子式: C₂₂H₁₂ClF₃N₂O₄
• 分子量: 460.79
• InChIKey: UAAUZNSONHHQQI-UHFFFAOYSA-N
• SMILES: O=C(O)c1ccc(-c2nc(C(=O)c3c(Cl)cccc3C(F)(F)F)n3ccccc23)cc1O

GNE-0946靶点实验

查看更多实验

实验名称：Lipophilicity, log D of the compound at pH 7.4 来源：ChEMBL 靶标：N/A External Id：CHEMBL3599865

实验名称：Oral bioavailability in Sprague-Dawley rat at 1.5 mg/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3598337

实验名称：Nuclear receptor ROR-gamma from US Patent US9550771: "Keto-imidazopyridine derivative... 来源：BindingDB 靶标：N/A External Id：BindingDB_424_1

实验名称：Antagonist activity at GAL4-fused human LXRbeta expressed in HEK293T cells assessed a... 来源：ChEMBL 靶标：Oxysterols receptor LXR-beta External Id：CHEMBL3600183

实验名称：Antagonist activity at GAL4-fused human PXR expressed in HEK293T cells assessed as in... 来源：ChEMBL 靶标：Nuclear receptor subfamily 1 group I member 2 External Id：CHEMBL3600184

实验名称：Antagonist activity at GAL4-fused human FXR expressed in HEK293T cells assessed as in... 来源：ChEMBL 靶标：Bile acid receptor External Id：CHEMBL3600181

实验名称：Antagonist activity at GAL4-fused human LXRalpha expressed in HEK293T cells assessed ... 来源：ChEMBL 靶标：Oxysterols receptor LXR-alpha External Id：CHEMBL3600182

实验名称：Selectivity ratio of EC50 for GAL4-fused human LXRalpha to EC50 for GAL4-fused human ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3600187

实验名称：Selectivity ratio of EC50 for GAL4-fused human LXRbeta to EC50 for GAL4-fused human R... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3600188

实验名称：Selectivity ratio of EC50 for GAL4-fused human FXR to EC50 for GAL4-fused human RORc 来源：ChEMBL 靶标：N/A External Id：CHEMBL3600186

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