DP00477

• 常用名: DP00477
• 英文名: DP00477
• CAS号: 169120-56-3
• 分子量: 397.80
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₁₁ClF₃N₃OS
• 熔点: N/A
• 闪点: N/A

DP00477用途

DP00477是一种有效的IDO1(吲哚胺2,3-双加氧酶1)抑制剂,IC50值为7.0µM。DP00477具有研究癌症的潜力[1]。

DP00477名称

• 英文名: DP00477

DP00477生物活性

• 描述: DP00477是一种有效的IDO1(吲哚胺2,3-双加氧酶1)抑制剂,IC50值为7.0µM。DP00477具有研究癌症的潜力[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 吲哚胺2,3-二氧化酶(IDO)
• 靶点实验:

  IDO1:7.0 μM (IC50)

• 体外研究: 当添加 5 mM谷胱甘肽或 0.01%Triton-X时,第00477页对 伊多1抑制性的 国际50值分别为 71,6.3µM[1]
• 参考文献:

  [1]. Röhrig UF, et al. Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. Eur J Med Chem. 2014 Sep 12;84:284-301.

DP00477物理化学性质

• 分子式: C₁₇H₁₁ClF₃N₃OS
• 分子量: 397.80
• InChIKey: JBTPUMQIJZGWRT-UHFFFAOYSA-N
• SMILES: N#CC(C(=O)Nc1cccc(C(F)(F)F)c1)C(=S)Nc1ccccc1Cl

DP00477靶点实验

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实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Screen for inhibitors of RMI FANCM (MM2) intereaction 来源：11908 靶标：N/A External Id：RMI-FANCM-MM2

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：Tautomerase Enzyme Assay from Article 10.1074/jbc.M110.113951: "Identification and ch... 来源：BindingDB 靶标：N/A External Id：BindingDB_5669_1

实验名称：The chemical genetic matrix (CGM) dataset as reported in Wildenhain et al. (2015) Pre... 来源：11924 靶标：N/A External Id：CGM data for Cell Systems paper Dec 2015

实验名称：A screen for compounds that inhibit viral RNA polymerase binding and polymerization a... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Chain A, Poliovirus Polymerase With Gtp External Id：HMS750

实验名称：Inhibition of mouse IDO1 expressed in mouse P815B cells using L-tryptophan substrate ... 来源：ChEMBL 靶标：Indoleamine 2,3-dioxygenase 1 External Id：CHEMBL3365095

实验名称：Inhibition of mouse TDO expressed in mouse P815B cells using L-tryptophan substrate i... 来源：ChEMBL 靶标：Tryptophan 2,3-dioxygenase External Id：CHEMBL3365096

实验名称：Inhibition of IDO1 (unknown origin) using L-tryptophan substrate incubated for 60 min... 来源：ChEMBL 靶标：Indoleamine 2,3-dioxygenase 1 External Id：CHEMBL3365093

实验名称：Inhibition of IDO1 (unknown origin) using L-tryptophan substrate incubated for 60 min... 来源：ChEMBL 靶标：Indoleamine 2,3-dioxygenase 1 External Id：CHEMBL3365094

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