胰高血糖素

更新时间:2024-01-02 14:11:55

胰高血糖素结构式
胰高血糖素结构式
品牌特惠专场
常用名 胰高血糖素 英文名 glucagonTFA
CAS号 16941-32-5 分子量 3482.747
密度 1.5±0.1 g/cm3 沸点 N/A
分子式 C153H225N43O49S 熔点 N/A
MSDS 中文版 美版 闪点 N/A

 胰高血糖素用途


Glucagon是一种多肽激素,有助于调节体内的血糖(葡萄糖)水平。

 胰高血糖素名称

中文名 胰高血糖素
英文名 glucagon
中文别名 高血糖素 | 盐酸高血糖素
英文别名 更多

 胰高血糖素生物活性

描述 Glucagon是一种多肽激素,有助于调节体内的血糖(葡萄糖)水平。
相关类别
体外研究 胰高血糖素可纠正DIO小鼠的血脂异常,肥胖和高血糖。当胰高血糖素与胰高血糖素受体结合时,肝细胞将糖原转化为单个葡萄糖分子并将其释放到血液中,这一过程称为糖原分解[1] [2]。
参考文献

[1]. Finan B et al. Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease. Cell. 2016 Oct 20;167(3):843-857.

[2]. Kristensen PL et al. Impact of the TCF7L2 genotype on risk of hypoglycaemia and glucagon secretion during hypoglycaemia. Endocr Connect. 2016 Oct 10.

 胰高血糖素物理化学性质

密度 1.5±0.1 g/cm3
分子式 C153H225N43O49S
分子量 3482.747
精确质量 3480.615723
PSA 1564.04000
LogP -6.01
外观性状 powder
折射率 1.682
储存条件 −20°C
稳定性

本品为二十九肽。由胰岛素A细胞分泌。低血糖时,其分泌正常,血浆半衰期约为3~6min。主要在肝脏灭活,经肾和血液者次之。含锌胰高血糖素的作用时间较长。人体在严重应激时有胰高血糖素的释放,无疑是一种生理性自身保护作用。如大面积烧伤、急性心肌梗塞伴有心原性休克、急性胰腺炎和外科手术后,血浆浓度明显升高。胰岛的A细胞增生或肿瘤也释放大量的胰高血糖素。

水溶解性 Practically insoluble in water and in most organic solvents. It is soluble in dilute mineral acids and in dilute solutions of alkali hydroxides.

 胰高血糖素安全信息

个人防护装备 Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码 NONH for all modes of transport
WGK德国 3

 胰高血糖素文献77

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 胰高血糖素英文别名

L-Threonine, L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-α-aspartyl-L-seryl-L-arginyl-L-argin yl-L-alanyl-L-glutaminyl-L-α-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-
Glucagon
L-Histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-α-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-α-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonine
GLUCAGON 1-37
His-ser-glu(nh2)-gly-thr-phe-thr-ser-asp-tyr-ser-lys-tyr-leu-asp-ser-arg-arg-ala-glu(NH2)-asp-phe-val-glu(NH2)-trp-leu-met-asp(NH2)-thr
L-threonine, L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-α-aspartyl-L-seryl-N-(diaminomethylene)-L-ornithyl-N-(diaminomethylene)-L-ornithyl-L-alanyl-L-glutaminyl-L-α-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-
L-Threonine, L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-α-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-α-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-
L-Histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-α-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L -glutaminyl-L-α-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonine
His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr
GLUCAGON ACETATE
OXYNTOMODULIN
GLUCAGON 37
L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-α-aspartyl-L-seryl-N-(diaminomethylidene)-L-ornithyl-N-(diaminomethylidene)-L-ornithyl-L-alanyl-L-glutaminyl-L-α-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonine
Glucagon 1-29
Glucaton
OXYNTOMODULIN (PORCINE)
Glucagon Hydrochloride
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