16941-32-5

• 常用中文名：胰高血糖素
• 常用英文名：glucagonTFA
• CAS号：16941-32-5
• 分子式：C₁₅₃H₂₂₅N₄₃O₄₉S
• 分子量：3482.747
• 相关类别： 原料药 激素及调节内分泌功能类药 胰腺激素及其它调节血糖药
• 发布时间：2018-07-10 11:00:43
• 更新时间：2026-07-01 21:46:23
• Glucagon是一种多肽激素,有助于调节体内的血糖(葡萄糖)水平。

名称

• 中文名: 胰高血糖素
• 英文名: glucagon
• 中文别名: CY7标记的胰高血糖素抗体; 高血糖素; ANTI-GLUCAGON ANTIBODY -胰高血糖素抗体; 盐酸高糖素; CY5.5标记的胰高血糖素抗体; 胰高血糖素杂质; 盐酸胰高血糖素、GLUCAGON; 胰高血糖素重组兔单抗; PE-CY7标记的胰高血糖素抗体; 盐酸胰高血糖素 GLUCAGONACETATE; PER-CY7标记的胰高血糖素抗体; 醋酸胰高血糖素 16-5; BF647标记的胰高血糖素抗体; BF555标记的胰高血糖素抗体; BF594标记的胰高血糖素抗体; 胰高血糖素 醋酸盐; PER-CY5.5标记的胰高血糖素抗体; BF405标记的胰高血糖素抗体; 胰高血糖素TFA; GLUCAGON HYDROCHLIDE 盐酸高血糖素; 人GLUCAGON肽; 高血糖素GLUCAGON; PE-CY5.5标记的胰高血糖素抗体; 胰高血糖素标准品; CY5标记的胰高血糖素抗体; BF488标记的胰高血糖素抗体; PACIFIC BLUE标记的胰高血糖素抗体; 盐酸高血糖素; APC标记的胰高血糖素抗体; BF680标记的胰高血糖素抗体; 胰高血糖素(GLU) 19ΜIU/19NG/支; BF350标记的胰高血糖素抗体; HRP标记的胰高血糖素抗体; APC-CY5.5标记的胰高血糖素抗体; 胰高血糖素,牛,人,猪; 醋酸胰高血糖素; RBITC标记的胰高血糖素抗体; BF750标记的胰高血糖素抗体; APC-CY7标记的胰高血糖素抗体; BIOTIN标记的胰高血糖素抗体; 泌酸调节蛋白(人,小鼠,大鼠)(三氟乙酸盐); BF700标记的胰高血糖素抗体; AP标记的胰高血糖素抗体; PE-CY5标记的胰高血糖素抗体; Glucagon , bovine, human-胰高血糖素; 高血糖素(GLUCAGON); 胰高血糖素 标准品; PER标记的胰高血糖素抗体; 胰高血糖素(GLU); CY3标记的胰高血糖素抗体; 牛、人、猪胰高血糖素; GLUCAGON 胰高血糖素; 胰高血糖素对照品; 胰高血糖素样肽 1 (GLP-1) 受体激动剂多肽; Glucagon , bovine, human试剂
• 英文别名: Glucagon, non animal source; Glucagon; rGlucagon (2 x 2.94 mg) (recombinant Glucagon (Human)) (COLD SHIPMENT REQUIRED); rGlucagon, recombinant glucagon (human); GLP-1, Insulinotropin; His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr; GlucagonQ: What is Glucagon Q: What is the CAS Number of Glucagon Q: What is the storage condition of Glucagon Q: What e the applications of Glucagon; Glucagon RS; GLUCAGON; GlucagonTFA; Glucagone; Glucagon HCI; Glukagon TFA; Glucagon , bovine, human, rat, porcine; piperazine-2,5-dione dioxime; Glucagon Hydrochloride; His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-g-g-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr; GLUCAGON 37; GLUCAGON EXTRACTED FROM PORCINE*PANCREAS GAMMA-IRRA; Glucagon 1-29; Glucagon (swine); 4-Amino-1-{5-O-[(9E)-9-octadecenoyl]-β-D-abinofuranosyl}-2(1H)- pyrimidinone; Glucagon Hydrochlide; Glucagon (human, rat, porcine); Glucagon (GLU); GLUCAGON FROM HOG PANCREAS, PACKAGE A; Glucagon Human HCl; Glucagon 4HCl; L-Histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-α-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-α-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonine; Glucagon (HUMAN) (2 x 2.94 mg) (COLD SHIPMENT REQUIRED); Glucagon,Porcine glucagon; Glucagon HCl; L-Histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-α-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L -glutaminyl-L-α-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonine; OXYNTOMODULIN; Glucagon Human Hydrochloride; GASTRIN RELEASING PTIDE, PROCINE; Glucagon impurity; GlucaGen; OXYNTOMODULIN (PORCINE); L-His-L-Ser-L-Gln-Gly-L-Thr-L-Phe-L-Thr-L-Ser-L-Asp-L-Tyr-L-Ser-L-Lys-L-Tyr-L-Leu-L-Asp-L-Ser-L-g-L-g-L-Ala-L-Gln-L-Asp-L-Phe-L-Val-L-Gln-L-Trp-L-Leu-L-Met-L-Asn-L-Thr-OH; Glucagon acetate; HSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNKNNIA; H-HIS-SER-GLN-GLY-THR-PHE-THR-SER-ASP-TYR-SER-LYS-TYR-LEU-ASP-SER-G-G-ALA-GLN-ASP-PHE-VAL-GLN-TRP-LEU-MET-ASN-THR-LYS-G-ASN-LYS-ASN-ASN-ILE-ALA-OH; Glucagonum; GLUCAGON 1-37; His-ser-glu(nh2)-gly-thr-phe-thr-ser-asp-tyr-ser-lys-tyr-leu-asp-ser-arg-arg-ala-glu(NH2)-asp-phe-val-glu(NH2)-trp-leu-met-asp(NH2)-thr; GLUCAGON (PORCINE); Human Gucagon; Glucagon //BP; GLUCAGON ACETATE; PORCINE GLUCAGON; Glucagon Acetate/Hcl; L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-α-aspartyl-L-seryl-N-(diaminomethylidene)-L-ornithyl-N-(diaminomethylidene)-L-ornithyl-L-alanyl-L-glutaminyl-L-α-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonine; Glucagon , Human, Hydrochloride Salt; Glucaton

物化性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₁₅₃H₂₂₅N₄₃O₄₉S
• 分子量: 3482.747
• 精确质量: 3480.615723
• PSA: 1564.04000
• LogP: -6.01
• 外观性状: powder
• 折射率: 1.682
• 储存条件: −20°C
• 稳定性:

  本品为二十九肽。由胰岛素Ａ细胞分泌。低血糖时，其分泌正常，血浆半衰期约为3～6min。主要在肝脏灭活，经肾和血液者次之。含锌胰高血糖素的作用时间较长。人体在严重应激时有胰高血糖素的释放，无疑是一种生理性自身保护作用。如大面积烧伤、急性心肌梗塞伴有心原性休克、急性胰腺炎和外科手术后，血浆浓度明显升高。胰岛的A细胞增生或肿瘤也释放大量的胰高血糖素。

• 水溶解性: Practically insoluble in water and in most organic solvents. It is soluble in dilute mineral acids and in dilute solutions of alkali hydroxides.

生物活性

• 描述: Glucagon是一种多肽激素,有助于调节体内的血糖(葡萄糖)水平。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 胰高血糖素受体
  研究领域 >> 代谢疾病
  多肽产品
  多肽产品
• 体外研究: 胰高血糖素可纠正DIO小鼠的血脂异常,肥胖和高血糖。当胰高血糖素与胰高血糖素受体结合时,肝细胞将糖原转化为单个葡萄糖分子并将其释放到血液中,这一过程称为糖原分解[1] [2]。
• 参考文献:

  [1]. Finan B et al. Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease. Cell. 2016 Oct 20;167(3):843-857.

  [2]. Kristensen PL et al. Impact of the TCF7L2 genotype on risk of hypoglycaemia and glucagon secretion during hypoglycaemia. Endocr Connect. 2016 Oct 10.

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3