咪达那新

• 常用名: 咪达那新
• 英文名: Imidafenacin
• CAS号: 170105-16-5
• 分子量: 319.400
• 密度: 1.1±0.1 g/cm3
• 沸点: 579.7±50.0 °C at 760 mmHg
• 分子式: C₂₀H₂₁N₃O
• 熔点: N/A
• 闪点: 304.4±30.1 °C

咪达那新用途

Imidafenacin(KRP-197; ONO-8025)是一种有效的和选择性的M3受体抑制剂，Kb值为0.317nM，对M2受体Kb值稍弱。

咪达那新名称

• 中文名: 咪达那新
• 英文名: 4-(2-methylimidazol-1-yl)-2,2-diphenylbutanamide

咪达那新生物活性

• 描述: Imidafenacin(KRP-197; ONO-8025)是一种有效的和选择性的M3受体抑制剂,Kb值为0.317nM,对M2受体Kb值稍弱。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  信号通路 >> 神经信号通路 >> mAChR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Miyachi H, et al. Synthesis and antimuscarinic activity of a series of 4-(1-Imidazolyl)-2,2-diphenylbutyramides: discovery of potent and subtype-selective antimuscarinic agents. Bioorg Med Chem. 1999 Jun;7(6):1151-61.

  [2]. Yamazaki T, et al. Imidafenacin has no influence on learning in nucleus basalis of Meynert-lesioned rats. Naunyn Schmiedebergs Arch Pharmacol. 2013 Dec;386(12):1095-102.

咪达那新物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 579.7±50.0 °C at 760 mmHg
• 分子式: C₂₀H₂₁N₃O
• 分子量: 319.400
• 闪点: 304.4±30.1 °C
• 精确质量: 319.168457
• PSA: 61.90000
• LogP: 2.42
• InChIKey: SQKXYSGRELMAAU-UHFFFAOYSA-N
• SMILES: Cc1nccn1CCC(C(N)=O)(c1ccccc1)c1ccccc1
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.603
• 储存条件: 2-8℃

咪达那新靶点实验

查看更多实验

实验名称：Antimuscarinic activity against muscarinic acetylcholine M3-receptor in guinea pig il... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor External Id：CHEMBL874696

实验名称：Antimuscarinic activity was evaluated against muscarinic M3 receptor in Guinea-Pig il... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor External Id：CHEMBL745483

实验名称：Selectivity ratio between Kb values of M2-receptor (atria) and M3-receptor (ileum) 来源：ChEMBL 靶标：Muscarinic acetylcholine receptors; M2 & M3 External Id：CHEMBL849679

实验名称：Antimuscarinic activity against M3 receptor of guinea pig ileum 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor External Id：CHEMBL745484

实验名称：ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake fl... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301363

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：Antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) measured by imaging in HR... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303810

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

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咪达那新英文别名

• Imidafenacin
• [14C]-Imidafenacin
• 4-(2-Methyl-imidazol-1-yl)-2,2-diphenyl-butyramide
• Staybla
• 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutyramide
• Imidafenacin (JAN/INN)
• 4-(2-Methyl-1H-imidazol-1-yl)-2,2-diphenylbutanamide
• Uritos (TN)
• Uritos
• Staybla (TN)