替唑尼特

• 常用名: 替唑尼特
• 英文名: Tizoxanide
• CAS号: 173903-47-4
• 分子量: 265.245
• 密度: 1.6±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₀H₇N₃O₄S
• 熔点: 279-281ºC(dec)
• 闪点: N/A

替唑尼特用途

Tizoxanide是Nitazoxanide活性代谢物，Nitazoxanide可抗细菌和多种病毒复制。

替唑尼特名称

• 中文名: 2-羟基-n-(5-硝基噻唑-2-基)苯甲酰胺
• 英文名: 2-hydroxy-N-(5-nitro-1,3-thiazol-2-yl)benzamide
• 中文别名: 替唑尼特

替唑尼特生物活性

• 描述: Tizoxanide是Nitazoxanide活性代谢物,Nitazoxanide可抗细菌和多种病毒复制。
• 相关类别:
  信号通路 >> 自噬 >> 自噬
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 参考文献:

  [1]. Korba BE, et al. Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication. Antiviral Res. 2008 Jan;77(1):56-63.

  [2]. Ashton LV, et al. In Vitro Susceptibility of Canine Influenza A (H3N8) Virus to Nitazoxanide and Tizoxanide. Vet Med Int. 2010 Aug 12;2010. pii: 891010.

  [3]. Korba BE, et al. Potential for hepatitis C virus resistance to nitazoxanide or tizoxanide. Antimicrob Agents Chemother. 2008 Nov;52(11):4069-71.

替唑尼特物理化学性质

• 密度: 1.6±0.1 g/cm3
• 熔点: 279-281ºC(dec)
• 分子式: C₁₀H₇N₃O₄S
• 分子量: 265.245
• 精确质量: 265.015717
• PSA: 136.28000
• LogP: 2.91
• InChIKey: FDTZUTSGGSRHQF-UHFFFAOYSA-N
• SMILES: O=C(Nc1ncc([N+](=O)[O-])s1)c1ccccc1O
• 外观性状: 固体;White to Orange to Green powder to crystal
• 折射率: 1.750
• 储存条件: 0-10°C;避免加热

替唑尼特靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Giardicidal activity against Giardia intestinalis IMSS:0696:1 compound treated for 48... 来源：ChEMBL 靶标：Giardia intestinalis External Id：CHEMBL3405796

实验名称：Confirmatory qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinas... 来源：NCGC External Id：IP6K1-f1-cherrypicks

实验名称：Inhibition of Giardia lamblia recombinant nitroreductase 1 (EAA43030.1) expressed in ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL938303

实验名称：Cytotoxicity against African green monkey Vero cells after 48 hrs by MTT assay 来源：ChEMBL 靶标：Vero External Id：CHEMBL3405797

实验名称：Antimicrobial activity against Staphylococcus epidermidis 9142 by microdilution metho... 来源：ChEMBL 靶标：Staphylococcus epidermidis External Id：CHEMBL1641278

实验名称：Trichomonicidal activity against Trichomonas vaginalis GT3 compound treated for 48 hr... 来源：ChEMBL 靶标：Trichomonas vaginalis External Id：CHEMBL3405795

实验名称：Antimicrobial activity against Staphylococcus epidermidis 5179 by microdilution metho... 来源：ChEMBL 靶标：Staphylococcus epidermidis External Id：CHEMBL1641279

实验名称：Inhibition of Giardia intestinalis fructose 1,6-bisphosphate aldolase at 400 nM after... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3405798

实验名称：Drug level in Sprague-Dawley rat treated with Nitazoxanide in plasma at 30 mg/kg, po ... 来源：ChEMBL 靶标：Plasma External Id：CHEMBL3998136

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替唑尼特英文别名

• 2-hydroxy-N-(5-nitrothiazol-2-yl)benzamide
• Tizoxanide
• Desacetylnitazoxanide
• Desacetyl-nitazoxanide
• NTZdes
• 2-Hydroxy-N-(5-nitro-1,3-thiazol-2-yl)benzamide
• 2-Hydroxy-N-(5-nitro-2-thiazolyl)benzamide