SYM2206

• 常用名: SYM2206
• 英文名: SYM2206
• CAS号: 173952-44-8
• 分子量: 366.41400
• 密度: 1.37g/cm3
• 沸点: N/A
• 分子式: C₂₀H₂₂N₄O₃
• 熔点: N/A
• 闪点: N/A

SYM2206用途

SYM 2206是一种新型, 非竞争的AMPA受体拮抗剂 (IC50= 2.8 μM)。

SYM2206名称

• 中文名: SYM2206
• 英文名: SYM 2206,(±)-4-(4-Aminophenyl)-1,2-dihydro-1-methyl-2-propylcarbamoyl-6,7-methylenedioxyphthalazine

SYM2206生物活性

• 描述: SYM 2206是一种新型, 非竞争的AMPA受体拮抗剂 (IC50= 2.8 μM)。
• 相关类别:
  信号通路 >> 跨膜转运 >> iGluR
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Jarogniew J. Luszczki,et al. SYM 2206 (a potent non-competitive AMPA receptor antagonist) elevates the threshold for maximal electroshock-induced seizures in mice. Curr. Issues Pharm. Med. Sci., Vol. 27, No. 2, Pages 80-83

SYM2206物理化学性质

• 密度: 1.37g/cm3
• 分子式: C₂₀H₂₂N₄O₃
• 分子量: 366.41400
• 精确质量: 366.16900
• PSA: 89.18000
• LogP: 3.59170
• InChIKey: OFUDZKKOKPGXOH-UHFFFAOYSA-N
• SMILES: CCCNC(=O)N1N=C(c2ccc(N)cc2)c2cc3c(cc2C1C)OCO3
• 折射率: 1.673
• 储存条件: 2-8℃

SYM2206靶点实验

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实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Inhibition of kainic acid induced AMPA receptor mediated current at 100 uM 来源：ChEMBL 靶标：Glutamate receptor 1 External Id：CHEMBL642064

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：Inhibition of KA induced currents associated with activation of the AMPA subtype of g... 来源：ChEMBL 靶标：Glutamate receptor 1 External Id：CHEMBL642068

实验名称：qHTS for Inhibitors of Polymerase Kappa 来源：NCGC 靶标：DNA polymerase kappa [Homo sapiens] External Id：PolK100

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：Inhibition of KA induced currents associated with activation of the AMPA subtype of g... 来源：ChEMBL 靶标：Glutamate receptor 1 External Id：CHEMBL642069

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

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SYM2206英文别名

• TRIS hydrochloride
• SYM 2206
• SYM2206