天名精内酯酮

• 常用名: 天名精内酯酮
• 英文名: Carabrone
• CAS号: 1748-81-8
• 分子量: 248.318
• 密度: 1.1±0.1 g/cm3
• 沸点: 397.4±15.0 °C at 760 mmHg
• 分子式: C₁₅H₂₀O₃
• 熔点: N/A
• 闪点: 176.5±20.4 °C

天名精内酯酮用途

Carabrone 天名精内酯酮从 Carpesium abrotanoides 的果实中分离出来,是一种倍半萜,具有显着的抗菌和抗肿瘤活性。Carabrone 在体内外具有抗真菌活性,抗灰霉病菌 Botrytis cinerea,炭疽病菌 Colletotrichum lagenarium 和禾白粉菌 Erysiphe graminis。

天名精内酯酮名称

• 中文名: 天名精内酯酮
• 英文名: (3aR,4aS,5S,5aR,6aR)-5a-methyl-3-methylidene-5-(3-oxobutyl)-3a,4,4a,5,6,6a-hexahydrocyclopropa[f][1]benzofuran-2-one

天名精内酯酮生物活性

• 描述: Carabrone 天名精内酯酮从 Carpesium abrotanoides 的果实中分离出来,是一种倍半萜,具有显着的抗菌和抗肿瘤活性。Carabrone 在体内外具有抗真菌活性,抗灰霉病菌 Botrytis cinerea,炭疽病菌 Colletotrichum lagenarium 和禾白粉菌 Erysiphe graminis。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 靶点实验:

  EC50: 7.10 μg/mL (Colletotrichum lagenarium)[1]

• 参考文献:

  [1]. Wang H, et al. Synthesis, antifungal activities and qualitative structure activity relationship of carabrone hydrazone derivatives as potential antifungal agents.

  [2]. Feng JT, et al. Synthesis and antifungal activity of carabrone derivatives. Molecules. 2010 Sep 16;15(9):6485-92.

天名精内酯酮物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 397.4±15.0 °C at 760 mmHg
• 分子式: C₁₅H₂₀O₃
• 分子量: 248.318
• 闪点: 176.5±20.4 °C
• 精确质量: 248.141251
• PSA: 43.37000
• LogP: 1.40
• InChIKey: AGIQIKMGJVLKMA-NLRWUALESA-N
• SMILES: C=C1C(=O)OC2CC3(C)C(CCC(C)=O)C3CC12
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.525
• 储存条件: 室温

天名精内酯酮安全信息

• 危害码 (欧洲): Xi

天名精内酯酮靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Antifungal activity against Candida albicans SC5314 assessed as inhibition of yeast c... 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL3632327

实验名称：Antifungal activity against Candida albicans SC5314 assessed as inhibition of biofilm... 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL3632326

实验名称：Inhibition of NO production in LPS/IFN-gamma activated mouse RAW264.7 cells after 24 ... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL3365201

实验名称：Inhibition of FMLP/CB-induced superoxide anion generation in human neutrophils at 10 ... 来源：ChEMBL 靶标：Neutrophil External Id：CHEMBL3362227

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：Inhibition of FMLP/CB-induced elastase release in human neutrophils after 5 mins by s... 来源：ChEMBL 靶标：Neutrophil External Id：CHEMBL3362230

实验名称：Inhibition of FMLP/CB-induced superoxide anion generation in human neutrophils by fer... 来源：ChEMBL 靶标：Neutrophil External Id：CHEMBL3362228

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Inhibition of FMLP/CB-induced elastase release in human neutrophils at 10 ug/ml after... 来源：ChEMBL 靶标：Neutrophil External Id：CHEMBL3362229

共26条，当前第1页，共3页

1

2

3

天名精内酯酮英文别名

• Carabron
• 5a-Methyl-3-methylene-5-(3-oxobutyl)octahydro-2H-cyclopropa[f][1]benzofuran-2-one
• Carabrone
• (3aR,4aS,5S,5aR,6aR)-5a-Methyl-3-methylene-5-(3-oxobutyl)octahydro-2H-cyclopropa[f][1]benzofuran-2-one