盐酸Piboserod

• 常用名: 盐酸Piboserod
• 英文名: Piboserod (hydrochloride)
• CAS号: 178273-87-5
• 分子量: 405.96100
• 密度: N/A
• 沸点: 570.3ºC at 760 mmHg
• 分子式: C₂₂H₃₂ClN₃O₂
• 熔点: N/A
• 闪点: 298.7ºC

盐酸Piboserod用途

Piboserod (SB 207266)盐酸盐是5-羟色胺受体5-HT4选择性抑制剂。

盐酸Piboserod名称

• 中文名: N-[(1-丁基-4-哌啶基)甲基]-3,4-二氢-2H-[1,3]噁嗪并[3,2-a]吲哚-10-羧胺盐酸盐
• 英文名: N-[(1-butylpiperidin-4-yl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide,hydrochloride

盐酸Piboserod生物活性

• 描述: Piboserod (SB 207266)盐酸盐是5-羟色胺受体5-HT4选择性抑制剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Darblade B, et al. Piboserod (SB 207266), a selective 5-HT4 receptor antagonist, reduces serotonin potentiation of neurally-mediated contractile responses of human detrusor muscle. World J Urol. 2005 Jun;23(2):147-51.

  [2]. Kjekshus JK, et al. Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure. Eur J Heart Fail. 2009 Aug;11(8):771-8.

  [3]. Nirogi R, et al. In-vivo rat striatal 5-HT4 receptor occupancy using non-radiolabelled SB207145. J Pharm Pharmacol. 2013 May;65(5):704-12.

盐酸Piboserod物理化学性质

• 沸点: 570.3ºC at 760 mmHg
• 分子式: C₂₂H₃₂ClN₃O₂
• 分子量: 405.96100
• 闪点: 298.7ºC
• 精确质量: 405.21800
• PSA: 46.50000
• LogP: 4.79650
• InChIKey: UABVCZHWRUGYSR-UHFFFAOYSA-N
• SMILES: CCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1.Cl
• 蒸汽压: 5.12E-13mmHg at 25°C
• 储存条件: 2-8℃

盐酸Piboserod英文别名

• UNII-61Z0VMM0AJ
• Piboserod HCl
• 2H-(1,3)Oxazino(3,2-a)indole-10-carboxamide,N-((1-butyl-4-piperidinyl)methyl)-3,4-dihydro-,monohydrochloride
• Piboserod hydrochloride
• Piboserod (hydrochloride)