Alcaftadine-D3

• 常用名: Alcaftadine-D3
• 英文名: Alcaftadine-D3
• CAS号: 1794775-80-6
• 分子量: 310.408
• 密度: 1.2±0.1 g/cm3
• 沸点: 556.2±60.0 °C at 760 mmHg
• 分子式: C₁₉H₁₈D₃N₃O
• 熔点: N/A
• 闪点: 290.2±32.9 °C

Alcaftadine-D3用途

Alcaftadine-D3 (R89674-D3) 是 Alcaftadine 的氘代物。Alcaftadine (HY-17039) 是 H1 组胺受体拮抗剂。

Alcaftadine-D3名称

• 中文名: 阿卡他定-d3
• 英文名: 11-[1-(2H3)Methyl-4-piperidinylidene]-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine-3-carbaldehyde

Alcaftadine-D3生物活性

• 描述: Alcaftadine-D3 (R89674-D3) 是 Alcaftadine 的氘代物。Alcaftadine (HY-17039) 是 H1 组胺受体拮抗剂。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 组胺受体
  研究领域 >> 内分泌
  研究领域 >> 炎症/免疫
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
• 参考文献:

  [1]. Namdar, R. and C. Valdez, Alcaftadine: a topical antihistamine for use in allergic conjunctivitis. Drugs Today (Barc), 2011. 47(12): p. 883-90.

Alcaftadine-D3物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 556.2±60.0 °C at 760 mmHg
• 分子式: C₁₉H₁₈D₃N₃O
• 分子量: 310.408
• 闪点: 290.2±32.9 °C
• 精确质量: 310.187286
• LogP: 3.20
• InChIKey: MWTBKTRZPHJQLH-FIBGUPNXSA-N
• SMILES: CN1CCC(=C2c3ccccc3CCn3c(C=O)cnc32)CC1
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.663
• 储存条件: 2-8°C

Alcaftadine-D3靶点实验

查看更多实验

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) measured by imaging in HR... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303810

实验名称：Protein binding in human plasma incubated for 240 mins by equilibrium dialysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4814321

实验名称：AUC (0 to infinity) in human at 0.25%, OU administered once daily for 7 days 来源：ChEMBL 靶标：N/A External Id：CHEMBL4814319

实验名称：Half life in human at 0.25%, OU administered once daily for 7 days 来源：ChEMBL 靶标：N/A External Id：CHEMBL4814320

实验名称：Drug metabolism in human assessed as half life of acid metabolite at 0.25%, OU admini... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4814325

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Half life in human liver supernatant 来源：ChEMBL 靶标：N/A External Id：CHEMBL4814326

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Alcaftadine-D3英文别名

• 11-[1-(2H3)Methyl-4-piperidinylidene]-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine-3-carbaldehyde