MZ 1

• 常用名: MZ 1
• 英文名: Mz1
• CAS号: 1797406-69-9
• 分子量: 1002.64
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₉H₆₀ClN₉O₈S₂
• 熔点: N/A
• 闪点: N/A

MZ 1用途

MZ 1 是基于 PROTAC 技术的 BRD4 蛋白质降解剂。

MZ 1名称

• 中文名: MZ 1
• 英文名: MZ 1

MZ 1生物活性

• 描述: MZ 1 是基于 PROTAC 技术的 BRD4 蛋白质降解剂。
• 相关类别:
  信号通路 >> 表观遗传学 >> 表观遗传读者域
  信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC
  研究领域 >> 癌症
• 靶点实验:

  BRD4[1]

• 参考文献:

  [1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.

MZ 1物理化学性质

• 分子式: C₄₉H₆₀ClN₉O₈S₂
• 分子量: 1002.64
• InChIKey: PTAMRJLIOCHJMQ-PYNGZGNASA-N
• SMILES: Cc1ncsc1-c1ccc(CNC(=O)C2CC(O)CN2C(=O)C(NC(=O)COCCOCCOCCNC(=O)CC2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)C(C)(C)C)cc1
• 储存条件: 2-8℃

MZ 1靶点实验

查看更多实验

实验名称：Binding affinity to BRD4 bromodomain 2 (unknown origin) assessed as gibbs free energy... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL5264534

实验名称：Protac activity at BRD4 short isoform in human MV4-11 cells assessed as recovery of B... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL5164043

实验名称：Binding affinity to N-terminal His6-tagged VHL (54 to 213 residues)/BRD4 BD2 (333 to ... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL5036178

实验名称：Permeability of the compound in PBS at pH 7.4 after 16 hrs by PAMPA 来源：ChEMBL 靶标：N/A External Id：CHEMBL5036177

实验名称：Antiproliferative activity against human 22Rv1 cells assessed as reduction in cell vi... 来源：ChEMBL 靶标：CWR22R External Id：CHEMBL5036176

实验名称：Antiproliferative activity against human MV4-11 cells assessed as reduction in cell v... 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL5036175

实验名称：Binding affinity to N-terminal His6-tagged VHL (54 to 213 residues) (unknown origin) ... 来源：ChEMBL 靶标：von Hippel-Lindau disease tumor suppressor External Id：CHEMBL5036179

实验名称：PROTAC activity at BRD4/VHL E3 ligase in human HCT116 p53+/+ cells assessed as decrea... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL5712712

实验名称：PROTAC activity at BRD4/VHL E3 ligase in human DLD-1 cells assessed as decrease in MY... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL5712711

实验名称：Displacement of (2S,4R)-N-(4-bromobenzyl)-4-hydroxy-1-(3,3,3-trifluoropropanoyl)pyrro... 来源：ChEMBL 靶标：Elongin-B External Id：CHEMBL5108379

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