3-氧代-12-烯-28-齐墩果酸

• 常用名: 3-氧代-12-烯-28-齐墩果酸
• 英文名: 3-oxo-Olean-12-en-28-oic acid
• CAS号: 17990-42-0
• 分子量: 454.684
• 密度: 1.1±0.1 g/cm3
• 沸点: 551.7±50.0 °C at 760 mmHg
• 分子式: C₃₀H₄₆O₃
• 熔点: N/A
• 闪点: 301.5±26.6 °C

3-氧代-12-烯-28-齐墩果酸用途

Oleanonic acid是一种三萜,可以抑制HIV-1对细胞的感染。起抑制HIV-1体外感染PBMC,自然感染PBMC和单核细胞/巨噬细胞的EC50分别为22.7mM,24.6mM和57.4mM。除此之外,它可以抑制鼠腹腔白细胞产生白三烯B4,IC50为17μm。

3-氧代-12-烯-28-齐墩果酸名称

• 中文名: 3-氧代-12-烯-28-齐墩果酸
• 英文名: (4aS,6aR,6aS,6bR,8aR,12aR,14bS)-2,2,6a,6b,9,9,12a-heptamethyl-10-oxo-3,4,5,6,6a,7,8,8a,11,12,13,14b-dodecahydro-1H-picene-4a-carboxylic acid
• 中文别名: 3-氧代-12-齐墩果烯-28-羧酸 | 齐墩果酮酸

3-氧代-12-烯-28-齐墩果酸生物活性

• 描述: Oleanonic acid是一种三萜,可以抑制HIV-1对细胞的感染。起抑制HIV-1体外感染PBMC,自然感染PBMC和单核细胞/巨噬细胞的EC50分别为22.7mM,24.6mM和57.4mM。除此之外,它可以抑制鼠腹腔白细胞产生白三烯B4,IC50为17μm。
• 相关类别:
  信号通路 >> 抗感染 >> HIV
  天然产物 >> 萜类化合物和糖苷
  研究领域 >> 癌症
• 参考文献:

  [1]. Giner-Larza EM et al.Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity.Eur J Pharmacol.Sep 28;428(1):137-43.doi:10.1016/S0014-2999(01)01290-0(2001)

  [2]. Fabio Mengoni.Anti-HIV Activity of Oleanolic Acid on Infected Human Mononuclear Cells.Planta Med 68(2): 111-114.DOI: 10.1055/s-2002-20256(2002)

3-氧代-12-烯-28-齐墩果酸物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 551.7±50.0 °C at 760 mmHg
• 分子式: C₃₀H₄₆O₃
• 分子量: 454.684
• 闪点: 301.5±26.6 °C
• 精确质量: 454.344696
• PSA: 54.37000
• LogP: 8.48
• InChIKey: FMIMFCRXYXVFTA-FUAOEXFOSA-N
• SMILES: CC1(C)CCC2(C(=O)O)CCC3(C)C(=CCC4C5(C)CCC(=O)C(C)(C)C5CCC43C)C2C1
• 蒸汽压: 0.0±3.2 mmHg at 25°C
• 折射率: 1.552
• 储存条件: -20°C

3-氧代-12-烯-28-齐墩果酸靶点实验

查看更多实验

实验名称：Inhibition of Ebola virus pseudoparticle GP HR2 domain-mediated viral entry into huma... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4712030

实验名称：Antiosteoclast activity in ICR mouse osteoblast like cells co-cultured with bone marr... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1058740

实验名称：Antiosteoclast activity in ICR mouse osteoblast like cells co-cultured with bone marr... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1058741

实验名称：Inhibition of rabbit muscle glycogen phosphorylase A assessed as phosphate release fr... 来源：ChEMBL 靶标：Glycogen phosphorylase, muscle form External Id：CHEMBL961425

实验名称：Percent inhibition of nitric oxide production induced by IFN-uM concentration 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL843091

实验名称：The compound was tested for its apoptotic activity; DNA migration observed as a smear... 来源：ChEMBL 靶标：N/A External Id：CHEMBL850486

实验名称：Inhibition of PTP1B (unknown origin) 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1 External Id：CHEMBL3055898

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 by BACTEC... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL966468

实验名称：Cytotoxicity against mock-infected human H9 cells after 4 days 来源：ChEMBL 靶标：H9 External Id：CHEMBL1004249

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3-氧代-12-烯-28-齐墩果酸英文别名

• oleanoic acid
• 3-oxooleana-12-en-28-oic acid
• Olean-12-en-28-oic acid,3-oxo
• oleanonic acid
• 3-oxo-oleanolic acid
• 3-Oxoolean-12-en-28-oic acid
• 3-keto oleanolic acid
• 3-oxo-olean-12-en-28-oic acid