索利那新盐酸盐

• 常用名: 索利那新盐酸盐
• 英文名: Solifenacin hydrochloride
• CAS号: 180468-39-7
• 分子量: 398.92600
• 密度: N/A
• 沸点: 505.5ºC at 760mmHg
• 分子式: C₂₃H₂₇ClN₂O₂
• 熔点: 120-122ºC
• 闪点: 259.5ºC

索利那新盐酸盐用途

Solifenacin(YM905; Vesicare)盐酸盐是毒蕈碱受体拮抗剂。

索利那新盐酸盐名称

• 中文名: 索利那新盐酸盐
• 英文名: Solifenacin Hydrochloride

索利那新盐酸盐生物活性

• 描述: Solifenacin(YM905; Vesicare)盐酸盐是毒蕈碱受体拮抗剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  信号通路 >> 神经信号通路 >> mAChR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Ronald A. Smulders et al. Pharmacokinetics and Safety of Solifenacin Succinate in Healthy Young Men. J Clin Pharmacol September 2004 vol. 44 no. 9 1023-1033

  [2]. Krishna SR, Rao BM, Rao NS.A validated rapid stability-indicating method for the determination of related substances in solifenacin succinate by ultra-fast liquid chromatography.J Chromatogr Sci. 2010 Nov;48(10):807-10.

  [3]. Ohtake A, Sato S, Sasamata M, Miyata K.The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: ameliorative effect of solifenacin succinate (Vesicare), a bladder-selective antimuscarinic agent, on overac

  [4]. Hoffstetter S, Leong FC.Solifenacin succinate for the treatment of overactive bladder.Expert Opin Drug Metab Toxicol. 2009 Mar;5(3):345-50.

  [5]. Choo MS, Lee JZ, Lee JB, Kim YH, Jung HC, Lee KS, Kim JC, Seo JT, Paick JS, Kim HJ, Na YG, Lee JG.Efficacy and safety of solifenacin succinate in Korean patients with overactive bladder: a randomised, prospective, double-blind, multicentre study.Int J Cli

索利那新盐酸盐物理化学性质

• 沸点: 505.5ºC at 760mmHg
• 熔点: 120-122ºC
• 分子式: C₂₃H₂₇ClN₂O₂
• 分子量: 398.92600
• 闪点: 259.5ºC
• 精确质量: 398.17600
• PSA: 32.78000
• LogP: 4.54270
• 蒸汽压: 2.41E-10mmHg at 25°C
• 储存条件: 2-8℃

索利那新盐酸盐英文别名

• [(3R)-1-azabicyclo[2.2.2]octan-3-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate,hydrochloride