P62-mediated mitophagy inducer

• 常用名: P62-mediated mitophagy inducer
• 英文名: P62-mediated mitophagy inducer
• CAS号: 1809031-84-2
• 分子量: 392.15
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₉IN₄O₂
• 熔点: N/A
• 闪点: N/A

P62-mediated mitophagy inducer用途

P62-mediated mitophagy inducer 是一种线粒体自噬调节剂,能激活线粒体噬但不招募 Parkin 或者使膜电位崩溃,且在缺乏完整功能的 PINK1/Parkin 通路的细胞中保留活性。

P62-mediated mitophagy inducer名称

• 中文名: P62-mediated mitophagy inducer
• 英文名: P62-mediated mitophagy inducer

P62-mediated mitophagy inducer生物活性

• 描述: P62-mediated mitophagy inducer 是一种线粒体自噬调节剂,能激活线粒体噬但不招募 Parkin 或者使膜电位崩溃,且在缺乏完整功能的 PINK1/Parkin 通路的细胞中保留活性。
• 相关类别:
  信号通路 >> 自噬 >> 自噬
  研究领域 >> 神经疾病
• 靶点实验:

  mitophagy[1]

• 参考文献:

  [1]. East DA, et al. PMI: a ΔΨm independent pharmacological regulator of mitophagy. Chem Biol. 2014 Nov 20;21(11):1585-96.

P62-mediated mitophagy inducer物理化学性质

• 分子式: C₁₄H₉IN₄O₂
• 分子量: 392.15
• 外观性状: 固体
• 储存条件: 2-8°C， 密封， 干燥

P62-mediated mitophagy inducer安全信息

• 危害码 (欧洲): Xn

P62-mediated mitophagy inducer靶点实验

查看更多实验

实验名称：Activation of Nrf2 in mouse Hepa1c1c7 cells assessed as induction of NQO1 production ... 来源：ChEMBL 靶标：Nuclear factor erythroid 2-related factor 2 External Id：CHEMBL3619968

实验名称：Solubility of the compound in 4 to 8% DMSO 来源：ChEMBL 靶标：N/A External Id：CHEMBL4376068

实验名称：Inhibition of kelch domain of Keap1 (unknown origin) interaction to high affinity ETG... 来源：ChEMBL 靶标：Kelch-like ECH-associated protein 1 External Id：CHEMBL3619967

实验名称：Increase of Nrf2 protein level in mouse Hepa1c1c7 cells at 10 uM after 24 hrs by West... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3620078

实验名称：Binding affinity to recombinant human KEAP1 Kelch domain (321 to 609 residues) expres... 来源：ChEMBL 靶标：Kelch-like ECH-associated protein 1 External Id：CHEMBL4376060

实验名称：Increase of Nrf2 protein level in mouse Hepa1c1c7 cells at 10 uM after 3 to 6 hrs by ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3620081

实验名称：Increase of Nrf2 protein level in mouse Hepa1c1c7 cells at 10 uM by Western blot anal... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3620080

实验名称：Binding affinity to recombinant human KEAP1 Kelch domain (321 to 609 residues) expres... 来源：ChEMBL 靶标：Kelch-like ECH-associated protein 1 External Id：CHEMBL4376062

实验名称：Inhibition of mCherry labeled Keap1 interaction to ETGE motif from Nrf2 in human HEK2... 来源：ChEMBL 靶标：Kelch-like ECH-associated protein 1 External Id：CHEMBL3620086

实验名称：Inhibition of mCherry labeled Keap1 interaction to DLG motif from Nrf2 in human HEK29... 来源：ChEMBL 靶标：Kelch-like ECH-associated protein 1 External Id：CHEMBL3620085

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P62-mediated mitophagy inducer英文别名

• MFCD31620757