Bevurogant

• 常用名: Bevurogant
• 英文名: Bevurogant
• CAS号: 1817773-66-2
• 分子量: 532.62
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₈N₈O₃S
• 熔点: N/A
• 闪点: N/A

Bevurogant用途

Bevurogant是一种与维甲酸相关的孤儿受体γt(RORγt)拮抗剂。Bevurogant可用于慢性炎症性疾病的研究[1]。

Bevurogant名称

• 英文名: Bevurogant

Bevurogant生物活性

• 描述: Bevurogant是一种与维甲酸相关的孤儿受体γt(RORγt)拮抗剂。Bevurogant可用于慢性炎症性疾病的研究[1]。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> ROR
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. BAKONYI J, et, al. Compounds as modulators of ror gamma. US20150291607A1.

Bevurogant物理化学性质

• 分子式: C₂₆H₂₈N₈O₃S
• 分子量: 532.62
• InChIKey: HVVHIBHBDCYLDI-HNNXBMFYSA-N
• SMILES: Cc1ncnc(C2CC2)c1-c1ncc2nc(NCc3ccc(S(C)(=O)=O)cn3)c(=O)n(C(C)C3CC3)c2n1

Bevurogant靶点实验

查看更多实验

实验名称：Oral bioavailability in Wistar Han rat at 3 mg/kg measured at 15 to 1440 mins 来源：ChEMBL 靶标：N/A External Id：CHEMBL4679764

实验名称：Inhibition of human ERG expressed in HEK293 cells assessed as reduction in channel ta... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL4679763

实验名称：Equilibrium solubility of compound in McIlvaine buffer at pH 7 incubated for 24 hrs u... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4679766

实验名称：Clearance in Wistar Han rat at 1 mg/kg, iv measured at 5 to 1440 mins relative to hep... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4679765

实验名称：Protein binding in human plasma at 1 uM measured after 3 to 6 hrs by equilibrium dial... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4679768

实验名称：Clearance in human Hepatocyte at 0.1 uM measured up to 240 mins by HPLC-MS/MS analysi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4679767

实验名称：Antagonist activity at RORgamma in human whole blood derived CD4-positive T cells ass... 来源：ChEMBL 靶标：Nuclear receptor ROR-gamma External Id：CHEMBL4679769

实验名称：In vivo antagonist activity at RORgamma in B10.RIII mouse IL-23 mini-circle model ass... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4679755

实验名称：Reporter Gene Assay from US Patent US9598415: "Compounds as modulators of RORγ" 来源：BindingDB 靶标：N/A External Id：BindingDB_1001_1

实验名称：Cardiotoxicity in anesthetized or telemetered Wistar Han rat assessed as effect on he... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4679762

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