Clausine E

• 常用名: Clausine E
• 英文名: Clausine E
• CAS号: 182261-83-2
• 分子量: 241.24
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₁NO₃
• 熔点: N/A
• 闪点: N/A

Clausine E用途

Clausene E是一种生物碱,是一种脂肪量和肥胖相关蛋白(FTO)去甲基化酶的抑制剂。黄嘌呤E对滑膜细胞和癌症细胞的增殖有抑制作用。

Clausine E名称

• 英文名: clausine E

Clausine E生物活性

• 描述: Clausene E是一种生物碱,是一种脂肪量和肥胖相关蛋白(FTO)去甲基化酶的抑制剂。黄嘌呤E对滑膜细胞和癌症细胞的增殖有抑制作用。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Wang Y, Li J, Han X, et al. Identification of Clausine E as an inhibitor of fat mass and obesity-associated protein (FTO) demethylase activity. J Mol Recognit. 2019;32(10):e2800.

  [2]. Guo JM, Yu XM, Jiang B, et al. Zhongguo Zhong Yao Za Zhi. 2021;46(17):4438-4445.

  [3]. Liger F, Popowycz F, Besson T, Picot L, Galmarini CM, Joseph B. Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres. Bioorg Med Chem. 2007;15(16):5615-5619.

Clausine E物理化学性质

• 分子式: C₁₄H₁₁NO₃
• 分子量: 241.24
• 精确质量: 241.07400
• PSA: 62.32000
• LogP: 2.81330
• InChIKey: ZWPODTIRGFOENJ-UHFFFAOYSA-N
• SMILES: COC(=O)c1cc(O)c2[nH]c3ccccc3c2c1
• 储存条件: 2-8°C，干燥，密封

Clausine E安全信息

• 危害码 (欧洲): Xi

Clausine E靶点实验

查看更多实验

实验名称：Cell cycle arrest in human L02 cells assessed as effect on cytoplasmic Chk1 protein l... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1931038

实验名称：Cell cycle arrest in human L02 cells assessed as effect on Chk1 protein level in nucl... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1931037

实验名称：Cell cycle arrest in human L02 cells assessed as effect on cytoplasmic Chk2 protein l... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1931122

实验名称：Cell cycle arrest in human L02 cells assessed as effect on Chk2 protein level in nucl... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1931121

实验名称：Inhibition of PKCdelta phosphorylation at Ser643 in human L02 cells by Western blot a... 来源：ChEMBL 靶标：Protein kinase C delta type External Id：CHEMBL1931124

实验名称：Inhibition of PKCdelta phosphorylation at Ser643 in human HepG2 cells by Western blot... 来源：ChEMBL 靶标：Protein kinase C delta type External Id：CHEMBL1931123

实验名称：Inhibition of PKCdelta phosphorylation at Thr505 in human L02 cells by Western blot a... 来源：ChEMBL 靶标：Protein kinase C delta type External Id：CHEMBL1931126

实验名称：Inhibition of PKCalpha/beta2 phosphorylation at Thr 638/641 in human HepG2 cells by W... 来源：ChEMBL 靶标：Protein kinase C alpha type External Id：CHEMBL1931125

实验名称：Cell cycle arrest in human HepG2 cells assessed as increase in cytoplasmic Chk1 prote... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL1931034

实验名称：Cell cycle arrest in human HepG2 cells assessed as decrease in Chk1 protein level in ... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL1931033

共51条，当前第1页，共6页

1

2

3

4

5

Clausine E英文别名

• methyl 1-hydroxy-9H-carbazole-3-carboxylate
• 1-Hydroxy-9H-carbazole-3-carboxylic acid methyl ester
• clauszoline I
• clauszoline-I
• clausine-E