PfDHODH-IN-1

• 常用名: PfDHODH-IN-1
• 英文名: PfDHODH-IN-1
• CAS号: 183945-55-3
• 分子量: 296.24
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₁F₃N₂O₂
• 熔点: N/A
• 闪点: N/A

PfDHODH-IN-1用途

PfDHODH-IN-1 是一种 Leflunomide 活性代谢物的类似物。PfDHODH-IN-1 是一种恶性疟原虫二氢乳清酸脱氢酶 (PfDHODH) 抑制剂。PfDHODH-IN-1 具有抗疟疾活性。

PfDHODH-IN-1名称

• 英文名: PfDHODH-IN-1

PfDHODH-IN-1生物活性

• 描述: PfDHODH-IN-1 是一种 Leflunomide 活性代谢物的类似物。PfDHODH-IN-1 是一种恶性疟原虫二氢乳清酸脱氢酶 (PfDHODH) 抑制剂。PfDHODH-IN-1 具有抗疟疾活性。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成
  信号通路 >> 代谢酶/蛋白酶 >> 乳酸脱氢酶
• 参考文献:

  [1]. Li SL, et al. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide. Int J Mol Sci. 2011;12(5):2982-93.

  [2]. Hou X, et al. QSAR study on the antimalarial activity of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors. SAR QSAR Environ Res. 2016;27(2):101-24.

PfDHODH-IN-1物理化学性质

• 分子式: C₁₄H₁₁F₃N₂O₂
• 分子量: 296.24
• 储存条件: 2-8°C，密封，干燥

PfDHODH-IN-1靶点实验

查看更多实验

实验名称：In vivo for its ability to inhibit delayed type hypersensitivity in mouse following 1... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL794676

实验名称：Inhibition of rat DHODH 来源：ChEMBL 靶标：Dihydroorotate dehydrogenase (quinone), mitochondrial External Id：CHEMBL907887

实验名称：Inhibition of Plasmodium falciparum HIs6-tagged DHODH expressed in Escherichia coli D... 来源：ChEMBL 靶标：Dihydroorotate dehydrogenase (quinone), mitochondrial External Id：CHEMBL3062604

实验名称：Inhibition of ubiquinone binding site of human dihydroorotate dehydrogenase 来源：ChEMBL 靶标：Dihydroorotate dehydrogenase (quinone), mitochondrial External Id：CHEMBL984852

实验名称：Inhibition of ubiquinone binding site of Plasmodium falciparum dihydroorotate dehydro... 来源：ChEMBL 靶标：Dihydroorotate dehydrogenase (quinone), mitochondrial External Id：CHEMBL984851

实验名称：t1/2 in mouse plasma after oral dose (30/mg/Kg) 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL633663

实验名称：Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouse 来源：ChEMBL 靶标：Dihydroorotate dehydrogenase (quinone), mitochondrial External Id：CHEMBL666232

实验名称：t1/2 in rat plasma after oral dose (10 mg/kg) 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL633664

实验名称：In vivo for its ability to inhibit delayed type hypersensitivity in mouse following 3... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL741843

实验名称：Inhibitory concentration tested against enzyme dihydroorotate dehydrogenase in rat 来源：ChEMBL 靶标：Dihydroorotate dehydrogenase (quinone), mitochondrial External Id：CHEMBL666233

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