(3S)-3-[[叔丁氧羰基]氨基]-5-氟-4-氧代-戊酸甲酯

更新时间：2024-01-10 06:40:45

(3S)-3-[[叔丁氧羰基]氨基]-5-氟-4-氧代-戊酸甲酯结构式	常用名	(3S)-3-[[叔丁氧羰基]氨基]-5-氟-4-氧代-戊酸甲酯	英文名	Boc-D-FMK
	CAS号	187389-53-3	分子量	263.263
	密度	1.1±0.1 g/cm3	沸点	383.5±37.0 °C at 760 mmHg
	分子式	C₁₁H₁₈FNO₅	熔点	N/A
	MSDS	中文版美版	闪点	185.7±26.5 °C

用途

Boc-Asp(OME)-氟甲基酮是一种广泛的caspase抑制剂,可抑制Fas介导的吞噬和氧化破裂抑制,但不影响IL-8的趋化活性[1][2]。

中文名	(3S)-3-[[叔丁氧羰基]氨基]-5-氟-4-氧代-戊酸甲酯
英文名	Boc-Asp(OMe)-fluoromethyl ketone
英文别名	更多

描述	Boc-Asp(OME)-氟甲基酮是一种广泛的caspase抑制剂,可抑制Fas介导的吞噬和氧化破裂抑制,但不影响IL-8的趋化活性[1][2]。
相关类别	信号通路 >> 细胞凋亡 >> 胱天蛋白酶研究领域 >> 炎症/免疫
靶点	Caspase
体外研究	Boc-Asp(OME)-氟甲基酮(100μM；30分钟；多形核白细胞)可防止Fas诱导的自发凋亡(−CH-11[1]。Boc-Asp(OME)-氟甲基酮(20μM；5小时；J774.1/JA-4细胞)显著增加LDH释放[2]。
参考文献	[1]. Paunel-Görgülü A, et al. Stimulation of Fas signaling down-regulates activity of neutrophils from major trauma patients with SIRS. Immunobiology. 2011;216(3):334-342. [2]. Koike A, et al. Pan-caspase inhibitors induce necroptosis via ROS-mediated activation of mixed lineage kinase domain-like protein and p38 in classically activated macrophages. Exp Cell Res. 2019;380(2):171-179.

密度	1.1±0.1 g/cm3
沸点	383.5±37.0 °C at 760 mmHg
分子式	C₁₁H₁₈FNO₅
分子量	263.263
闪点	185.7±26.5 °C
精确质量	263.116913
PSA	81.70000
LogP	1.91
蒸汽压	0.0±0.9 mmHg at 25°C
折射率	1.440
储存条件	-20°C，密闭，干燥

MSDS英文版

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
安全声明 (欧洲)	22-24/25
危险品运输编码	NONH for all modes of transport
海关编码	2924199090

海关编码	2924199090
中文概述	2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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