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(3S)-3-[[叔丁氧羰基]氨基]-5-氟-4-氧代-戊酸甲酯

更新时间:2025-08-25 15:37:00

(3S)-3-[[叔丁氧羰基]氨基]-5-氟-4-氧代-戊酸甲酯结构式
(3S)-3-[[叔丁氧羰基]氨基]-5-氟-4-氧代-戊酸甲酯结构式
品牌特惠专场
常用名 (3S)-3-[[叔丁氧羰基]氨基]-5-氟-4-氧代-戊酸甲酯 英文名 Boc-D-FMK
CAS号 187389-53-3 分子量 263.263
密度 1.1±0.1 g/cm3 沸点 383.5±37.0 °C at 760 mmHg
分子式 C11H18FNO5 熔点 N/A
MSDS 中文版 美版 闪点 185.7±26.5 °C

 用途


Boc-Asp(OME)-氟甲基酮是一种广泛的caspase抑制剂,可抑制Fas介导的吞噬和氧化破裂抑制,但不影响IL-8的趋化活性[1][2]。

 名称

中文名 (3S)-3-[[叔丁氧羰基]氨基]-5-氟-4-氧代-戊酸甲酯
英文名 Boc-Asp(OMe)-fluoromethyl ketone
英文别名 更多

 生物活性

描述 Boc-Asp(OME)-氟甲基酮是一种广泛的caspase抑制剂,可抑制Fas介导的吞噬和氧化破裂抑制,但不影响IL-8的趋化活性[1][2]。
相关类别
靶点

Caspase

体外研究 Boc-Asp(OME)-氟甲基酮(100μM;30分钟;多形核白细胞)可防止Fas诱导的自发凋亡(−CH-11[1]。Boc-Asp(OME)-氟甲基酮(20μM;5小时;J774.1/JA-4细胞)显著增加LDH释放[2]。
参考文献

[1]. Paunel-Görgülü A, et al. Stimulation of Fas signaling down-regulates activity of neutrophils from major trauma patients with SIRS. Immunobiology. 2011;216(3):334-342.

[2]. Koike A, et al. Pan-caspase inhibitors induce necroptosis via ROS-mediated activation of mixed lineage kinase domain-like protein and p38 in classically activated macrophages. Exp Cell Res. 2019;380(2):171-179.

 物理化学性质

密度 1.1±0.1 g/cm3
沸点 383.5±37.0 °C at 760 mmHg
分子式 C11H18FNO5
分子量 263.263
闪点 185.7±26.5 °C
精确质量 263.116913
PSA 81.70000
LogP 1.91
蒸汽压 0.0±0.9 mmHg at 25°C
折射率 1.440
储存条件 -20°C,密闭,干燥

 MSDS

 安全信息

个人防护装备 Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
安全声明 (欧洲) 22-24/25
危险品运输编码 NONH for all modes of transport
海关编码 2924199090

 海关

海关编码 2924199090
中文概述 2924199090. 其他无环酰胺(包括无环氨基甲酸酯)(包括其衍生物及盐). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素 品名, 成分含量, 用途, 包装
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 文献4

更多文献
C1 Domain-targeted isophthalate derivatives induce cell elongation and cell cycle arrest in HeLa cells.

PLoS ONE 6 , e20053, (2011)

Diacylglycerol (DAG)-mediated signaling pathways, such as those mediated by protein kinase C (PKC), are central in regulating cell proliferation and apoptosis. DAG-responsive C1 domains are therefore ...

Caspase inhibitors promote the survival of avulsed spinal motoneurons in neonatal rats.

Neuroreport 12 , 541, (2001)

Following ventral root avulsion in neonatal animals, the degeneration of spinal motoneurons occurs by an apoptotic-like morphological pathway. In adult animals, however, the mechanism of degeneration ...

The maternal-effect gene cellular island encodes aurora B kinase and is essential for furrow formation in the early zebrafish embryo.

PLoS Genet. 5 , e1000518, (2009)

Females homozygous for a mutation in cellular island (cei) produce embryos with defects in cytokinesis during early development. Analysis of the cytoskeletal events associated with furrow formation re...

 英文别名

Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester, (3S)-
pentanoic acid, 3-[[(1E)-(1,1-dimethylethoxy)hydroxymethylene]amino]-5-fluoro-4-oxo-, methyl ester, (3S)-
caspase inhibitor3
Methyl (3S)-5-fluoro-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-4-oxopentanoate
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