GRP78-IN-2

• 常用名: GRP78-IN-2
• 英文名: GRP78-IN-2
• CAS号: 1882875-63-9
• 分子量: 487.54
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₂₉NO₆
• 熔点: N/A
• 闪点: N/A

GRP78-IN-2用途

GRP78-IN-2(化合物FL5)是GRP78(葡萄糖调节蛋白78 kDa)抑制剂。GRP78-IN-2优先针对细胞表面GRP78,并显示出强大的抗血管生成和抗癌活性,而不影响其他正常细胞[1]。

GRP78-IN-2名称

• 英文名: GRP78-IN-2

GRP78-IN-2生物活性

• 描述: GRP78-IN-2(化合物FL5)是GRP78(葡萄糖调节蛋白78 kDa)抑制剂。GRP78-IN-2优先针对细胞表面GRP78,并显示出强大的抗血管生成和抗癌活性,而不影响其他正常细胞[1]。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 心血管疾病
  信号通路 >> 代谢酶/蛋白酶 >> HSP
  信号通路 >> 细胞周期/DNA损伤 >> HSP
• 参考文献:

  [1]. Qiao Y, et al. Discovery of small molecules targeting GRP78 for antiangiogenic and anticancer therapy. Eur J Med Chem. 2020 May 1;193:112228.

GRP78-IN-2物理化学性质

• 分子式: C₂₉H₂₉NO₆
• 分子量: 487.54

GRP78-IN-2靶点实验

查看更多实验

实验名称：Binding affinity to N-terminal His-tagged GRP78 (unknown origin) assessed as change i... 来源：ChEMBL 靶标：Endoplasmic reticulum chaperone BiP External Id：CHEMBL4686299

实验名称：Cytotoxicity against mouse Swiss-3T3 cells assessed as reduction in cell viability up... 来源：ChEMBL 靶标：NIH3T3 External Id：CHEMBL4686300

实验名称：Inhibition of Staphylococcus aureus Sortase A delta 59 mutant using Abz-LPATG-Dnp as ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3879362

实验名称：Antiangiogenic activity against VEGF-stimulated HUVEC assessed as reduction in cell v... 来源：ChEMBL 靶标：HUVEC External Id：CHEMBL4686291

实验名称：Binding affinity to human GRP78 at 1 uM measured after 30 mins by UF-ASMS analysis re... 来源：ChEMBL 靶标：Endoplasmic reticulum chaperone BiP External Id：CHEMBL4686292

实验名称：Antiangiogenic activity against VEGF-stimulated HUVEC assessed as reduction in cell v... 来源：ChEMBL 靶标：HUVEC External Id：CHEMBL4686295

实验名称：Cytotoxicity against human 786-0 cells assessed reduction in cell viability after 48 ... 来源：ChEMBL 靶标：786-0 External Id：CHEMBL4686296

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