Olutasidenib

• 常用名: Olutasidenib
• 英文名: Olutasidenib
• CAS号: 1887014-12-1
• 分子量: 354.79
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₅ClN₄O₂
• 熔点: N/A
• 闪点: N/A

Olutasidenib用途

Olutasidenib是一种突变型异柠檬酸脱氢酶 (IDH)1 的选择性有效抑制剂,可用于治疗急性髓性白血病。

Olutasidenib名称

• 中文名: Olutasidenib
• 英文名: Olutasidenib

Olutasidenib生物活性

• 描述: Olutasidenib是一种突变型异柠檬酸脱氢酶 (IDH)1 的选择性有效抑制剂,可用于治疗急性髓性白血病。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 异柠檬酸脱氢酶(IDH)
  研究领域 >> 炎症/免疫
• 靶点实验:

  IDH1[1].

• 参考文献:

  [1]. JM Watts, et al. A phase 1 dose escalation study of the IDH1m inhibitor, FT-2102, in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).

Olutasidenib物理化学性质

• 分子式: C₁₈H₁₅ClN₄O₂
• 分子量: 354.79
• InChIKey: NEQYWYXGTJDAKR-JTQLQIEISA-N
• SMILES: CC(Nc1ccc(C#N)n(C)c1=O)c1cc2cc(Cl)ccc2[nH]c1=O
• 储存条件: -20°C，密闭，干燥

Olutasidenib靶点实验

查看更多实验

实验名称：Inhibition of IDH1 R132C mutant in human HCT116 cells assessed as reduction in 2-HG l... 来源：ChEMBL 靶标：Isocitrate dehydrogenase [NADP] cytoplasmic External Id：CHEMBL4325710

实验名称：Inhibition of IDH1 R132H mutant in human HCT116 cells assessed as reduction in 2-HG l... 来源：ChEMBL 靶标：Isocitrate dehydrogenase [NADP] cytoplasmic External Id：CHEMBL4325709

实验名称：Brain to plasma ratio in mouse at 50 mg/kg, iv 来源：ChEMBL 靶标：N/A External Id：CHEMBL5625298

实验名称：Metabolic stability in mouse liver microsomes assessed as parent compound remaining a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4325708

实验名称：Metabolic stability in human liver microsomes assessed as parent compound remaining a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4325707

实验名称：In vivo inhibition of IDH1 R132C mutant in human HCT116 cells xenografted in BALB/c n... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4325720

实验名称：In vivo inhibition of IDH1 R132H mutant in human HCT116 cells xenografted in BALB/c n... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4325719

实验名称：In vivo inhibition of IDH1 R132H mutant in human HCT116 cells xenografted in po dosed... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4325718

实验名称：Enzymatic Assay from US Patent US11566013: "Inhibiting mutant isocitrate dehydrogenas... 来源：BindingDB 靶标：N/A External Id：BindingDB_11111_1

实验名称：Efflux ratio of apparent permeability across apical to basolateral side in human Caco... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5625306

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