Wistin

更新时间：2025-08-25 00:55:05

Wistin结构式	常用名	Wistin	英文名	Wistin
	CAS号	19046-26-5	分子量	460.43100
	密度	N/A	沸点	N/A
	分子式	C₂₃H₂₄O₁₀	熔点	N/A
	MSDS	N/A	闪点	N/A

Wistin用途

Wistin 可从 Caragana sinica 根部分离得到,是 PPARα 和 PPARγ 的激动剂。

英文名	wistin
英文别名	更多

描述	Wistin 可从 Caragana sinica 根部分离得到,是 PPARα 和 PPARγ 的激动剂。
相关类别	研究领域 >> 癌症信号通路 >> 细胞周期/DNA损伤 >> PPAR 研究领域 >> 代谢疾病
体外研究	威斯汀,是一个PPARγ 能诱导PPAR mRNA表达的激动剂γ 小鼠3T3-L1细胞中的靶基因脂联素[2]。Wistin抑制肝细胞内甘油三酯的积聚(10时P<0.05)μg/mL),并呈剂量依赖性[2]。威斯汀(10)μg/mL)导致CPT1a、ACO和ACS的表达水平分别增加2.5倍、7.2倍和14.8倍[2]。Wistin治疗48h后,小鼠原代肝细胞TG含量显著降低,且呈剂量依赖性[2]。wistin处理增强了脂肪细胞分化的标志物,如3T3-L1细胞中甘油三酯的积累[3]。RT-PCR[2]细胞系：小鼠肝细胞。浓度：1或10μg/mL。培养时间：48小时。结果：PPAR显著升高α mRNA水平呈剂量依赖性。
参考文献	[1]. SeonJu Park, et al. Neuraminidase Inhibitors from the Roots of Caragana sinica. Chem Biodivers. 2020 Nov;17(11):e2000470. [2]. Misato Suzuki, et al. 4',6-Dimethoxyisoflavone-7-O-β-D-glucopyranoside (wistin) is a peroxisome proliferator-activated receptor α (PPARα) agonist in mouse hepatocytes. Mol Cell Biochem. 2018 Sep;446(1-2):35-41. [3]. Matoki Sanada, et al. 4',6-dimethoxyisoflavone-7-O-β-D-glucopyranoside (wistin) is a peroxisome proliferator-activated receptor γ (PPARγ) agonist that stimulates adipocyte differentiation. Anim Sci J. 2016 Nov;87(11):1347-1351.

分子式	C₂₃H₂₄O₁₀
分子量	460.43100
精确质量	460.13700
PSA	148.05000
LogP	0.65590
InChIKey	YLYJXNTZVUEFJZ-DODNOZFWSA-N
SMILES	COc1ccc(-c2coc3cc(OC4OC(CO)C(O)C(O)C4O)c(OC)cc3c2=O)cc1

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