BMS-986205

• 常用名: BMS-986205
• 英文名: Linrodostat (BMS-986205)
• CAS号: 1923833-60-6
• 分子量: 410.15
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₄ClFN₂O
• 熔点: N/A
• 闪点: N/A

BMS-986205用途

BMS-986205 是一个有选择性的吲哚胺 2,3-双加氧酶 1 (IDO1) 抑制剂。

BMS-986205名称

• 中文名: BMS-986205
• 英文名: BMS-986205

BMS-986205生物活性

• 描述: BMS-986205 是一个有选择性的吲哚胺 2,3-双加氧酶 1 (IDO1) 抑制剂。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 吲哚胺2,3-二氧化酶(IDO)
  研究领域 >> 癌症
• 靶点实验:

  IDO1

• 参考文献:

  [1]. Lillian L. Siu, et al. Abstract CT116: BMS-986205, an optimized indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, is well tolerated with potent pharmacodynamic (PD) activity, alone and in combination with nivolumab (nivo) in advanced cancers in a phase 1/2a trial. AACR; Cancer Res. 2017; 77 (13 Suppl): Abstract nr CT116.

BMS-986205物理化学性质

• 分子式: C₂₄H₂₄ClFN₂O
• 分子量: 410.15
• 外观性状: 粉末
• 储存条件: -20℃

BMS-986205靶点实验

查看更多实验

实验名称：In vivo inhibition of IDO1 in human patient assessed as reduction in Serum kynurenine... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL4355099

实验名称：In vivo inhibition of IDO1 in mouse xenografted with human SKOV3 cells assessed as re... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4725208

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：AUC (0 to 24 hrs) in mouse xenografted with human SKOV3 cells assessed in tumor at 60... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4725206

实验名称：In vivo inhibition of IDO1 in mouse xenografted with human SK-OV-3 cells assessed as ... 来源：ChEMBL 靶标：Indoleamine 2,3-dioxygenase 1 External Id：CHEMBL4824908

实验名称：qHTS drug screen for cell cycle checkpoint inhibitors in PARPi-resistant BRCA-mutant ... 来源：NCGC External Id：FGL-PARP_PEO-CTG96h-MIPE5.0-p1

实验名称：AUC (0 to 24 hrs) in human SK-OV-3 cells xenografted in nu/nu mouse xenograft model m... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4824905

实验名称：In vivo inhibition of IDO1 in mouse assessed as reduction in LPS-induced kynurenine l... 来源：ChEMBL 靶标：Indoleamine 2,3-dioxygenase 1 External Id：CHEMBL4679061

实验名称：Metabolic stability in human hepatocytes assessed as half life 来源：ChEMBL 靶标：N/A External Id：CHEMBL4679064

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