GW311616盐酸盐

• 常用名: GW311616盐酸盐
• 英文名: GW311616A
• CAS号: 197890-44-1
• 分子量: 433.993
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₃₂ClN₃O₄S
• 熔点: N/A
• 闪点: N/A

GW311616盐酸盐用途

GW311616A(GW311616盐酸盐)是高活性，可渗透入细胞，口服生物相容性，长效的人中性白细胞弹性蛋白酶（HNE）抑制剂，IC50为22 nM。

GW311616盐酸盐名称

• 中文名: GW311616盐酸盐
• 英文名: GW311616 hydrochloride

GW311616盐酸盐生物活性

• 描述: GW311616A(GW311616盐酸盐)是高活性,可渗透入细胞,口服生物相容性,长效的人中性白细胞弹性蛋白酶(HNE)抑制剂,IC50为22 nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 弹性蛋白酶
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Macdonald SJ, et al. The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate. Bioorg Med Chem Lett. 2001 Apr 9;11(7):895-8.

GW311616盐酸盐物理化学性质

• 分子式: C₁₉H₃₂ClN₃O₄S
• 分子量: 433.993
• 精确质量: 433.180206
• InChIKey: UFCZUKYPBPXODT-OFTZGUNKSA-N
• SMILES: CC(C)C1C(=O)N(S(C)(=O)=O)C2CCN(C(=O)C=CCN3CCCCC3)C12.Cl
• 储存条件: 2-8℃

GW311616盐酸盐靶点实验

查看更多实验

实验名称：pharmacokinetic parameter area under the curve (AUC) was reported in dog after intrav... 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL641493

实验名称：pharmacokinetic parameter area under the curve (AUC) was reported in dog after oral a... 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL641494

实验名称：The compound was evaluated for its % Elastase inhibition in bone marrow at a concentr... 来源：ChEMBL 靶标：Neutrophil elastase External Id：CHEMBL695325

实验名称：pharmacokinetic parameter area under the curve (AUC) was reported in rat after intrav... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL641495

实验名称：half life was reported in dog after intravenous administration 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL641636

实验名称：Pharmacokinetic parameter Tmax was reported in dog after oral administration 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL638504

实验名称：pharmacokinetic parameter area under the curve (AUC) was reported in rat after oral a... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL641496

实验名称：Dissociation rate constant at pH 7.4 against Elastase 来源：ChEMBL 靶标：Neutrophil elastase External Id：CHEMBL674809

实验名称：Pharmacokinetic parameter Tmax was reported in rat after intravenous administration 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL873349

实验名称：half life was reported in dog after oral administration 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL641637

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GW311616盐酸盐英文别名

• GW-311616A
• (3S,3aS,6aR)-3-Isopropyl-1-(methylsulfonyl)-4-[(2E)-4-(1-piperidinyl)-2-butenoyl]hexahydropyrrolo[3,2-b]pyrrol-2(1H)-one hydrochloride (1:1)
• 171SKM32U6
• MFCD06411566
• Pyrrolo[3,2-b]pyrrol-2(1H)-one, hexahydro-3-(1-methylethyl)-1-(methylsulfonyl)-4-[(2E)-1-oxo-4-(1-piperidinyl)-2-buten-1-yl]-, (3S,3aS,6aR)-, hydrochloride (1:1)
• GW311616 (hydrochloride)
• GW311616A