GW311616A
Modify Date: 2024-01-08 15:04:27
GW311616A structure
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Common Name | GW311616A | ||
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| CAS Number | 197890-44-1 | Molecular Weight | 433.993 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H32ClN3O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GW311616AGW311616A(GW311616 Hcl) is a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase(HNE) with IC50 of 22 nM.IC50 value: 22 nM [1]Target: neutrophil elastaseThe HNE inhibitor GW311616A is selective over other human serine proteases (IC50 values >100 uM for trypsin, cathepsin G, and plasmin, >3 mM for chymotrypsin and tissue plasminogen activator). Acetylcholinesterase is not inhibited by GW311616A at 100 uM.GW311616A is more potent than thetrifluoromethylketone inhibitor ZD8321 (Ki=13 nM). GW311616A is orallybioavailable in rat, dog (Table 4) and hamster despite moderate to high plasmaclearance, which indicates that clearance is predominantly extrahepatic. |
| Name | GW311616 hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | GW311616A(GW311616 Hcl) is a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase(HNE) with IC50 of 22 nM.IC50 value: 22 nM [1]Target: neutrophil elastaseThe HNE inhibitor GW311616A is selective over other human serine proteases (IC50 values >100 uM for trypsin, cathepsin G, and plasmin, >3 mM for chymotrypsin and tissue plasminogen activator). Acetylcholinesterase is not inhibited by GW311616A at 100 uM.GW311616A is more potent than thetrifluoromethylketone inhibitor ZD8321 (Ki=13 nM). GW311616A is orallybioavailable in rat, dog (Table 4) and hamster despite moderate to high plasmaclearance, which indicates that clearance is predominantly extrahepatic. |
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| Related Catalog | |
| References |
| Molecular Formula | C19H32ClN3O4S |
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| Molecular Weight | 433.993 |
| Exact Mass | 433.180206 |
| Storage condition | 2-8℃ |
| GW-311616A |
| (3S,3aS,6aR)-3-Isopropyl-1-(methylsulfonyl)-4-[(2E)-4-(1-piperidinyl)-2-butenoyl]hexahydropyrrolo[3,2-b]pyrrol-2(1H)-one hydrochloride (1:1) |
| 171SKM32U6 |
| MFCD06411566 |
| Pyrrolo[3,2-b]pyrrol-2(1H)-one, hexahydro-3-(1-methylethyl)-1-(methylsulfonyl)-4-[(2E)-1-oxo-4-(1-piperidinyl)-2-buten-1-yl]-, (3S,3aS,6aR)-, hydrochloride (1:1) |
| GW311616 (hydrochloride) |
| GW311616A |