盐酸瑞伐拉赞

• 常用名: 盐酸瑞伐拉赞
• 英文名: Revaprazan
• CAS号: 199463-33-7
• 分子量: 362.44300
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₃FN₄
• 熔点: N/A
• 闪点: N/A

盐酸瑞伐拉赞用途

Revaprazan(SB 641257)是一种可逆的质子泵抑制剂,具有显著的抗炎作用。Revaprazan可用于慢性胃炎研究[1][2]。

盐酸瑞伐拉赞名称

• 中文名: 盐酸瑞伐拉赞
• 英文名: N-(4-fluorophenyl)-4,5-dimethyl-6-[(1S)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]pyrimidin-2-amine

盐酸瑞伐拉赞生物活性

• 描述: Revaprazan(SB 641257)是一种可逆的质子泵抑制剂,具有显著的抗炎作用。Revaprazan可用于慢性胃炎研究[1][2]。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> 跨膜转运 >> 质子泵
• 参考文献:

  [1]. Li W, et al. Preparation and in vitro/in vivo evaluation of revaprazan hydrochloride nanosuspension. Int J Pharm. 2011 Apr 15;408(1-2):157-62.

  [2]. Lee JS, et al. Revaprazan, a novel acid pump antagonist, exerts anti-inflammatory action against Helicobacter pylori-induced COX-2 expression by inactivating Akt signaling. J Clin Biochem Nutr. 2012 Sep;51(2):77-83.

盐酸瑞伐拉赞物理化学性质

• 分子式: C₂₂H₂₃FN₄
• 分子量: 362.44300
• 精确质量: 362.19100
• PSA: 41.05000
• LogP: 5.23780
• InChIKey: LECZXZOBEZITCL-UHFFFAOYSA-N
• SMILES: Cc1nc(Nc2ccc(F)cc2)nc(N2CCc3ccccc3C2C)c1C
• 储存条件: 室温

盐酸瑞伐拉赞靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4651404

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

共36条，当前第1页，共4页

1

2

3

4

盐酸瑞伐拉赞英文别名

• Revaprazan [INN]