VPC-14228

• 常用名: VPC-14228
• 英文名: VPC-14228
• CAS号: 19983-28-9
• 分子量: 246.32800
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₃H₁₄N₂OS
• 熔点: N/A
• 闪点: N/A
• 符号: GHS07
• 信号词: Warning

VPC-14228用途

VPC-14228是一种有效的雄激素受体DNA结合域(AR-DBD)抑制剂,它干扰AR与雄激素应答元件的相互作用,并有效阻断AR转录活性。VPC-14228可用于前列腺癌研究[1]。

VPC-14228名称

• 英文名: 4-(4-phenyl-1,3-thiazol-2-yl)morpholine

VPC-14228生物活性

• 描述: VPC-14228是一种有效的雄激素受体DNA结合域(AR-DBD)抑制剂,它干扰AR与雄激素应答元件的相互作用,并有效阻断AR转录活性。VPC-14228可用于前列腺癌研究[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 雄激素受体
• 参考文献:

  [1]. Kush Dalal, et al. Selectively targeting the DNA-binding domain of the androgen receptor as a prospective therapy for prostate cancer. J Biol Chem. 2014 Sep 19;289(38):26417-26429.

VPC-14228物理化学性质

• 分子式: C₁₃H₁₄N₂OS
• 分子量: 246.32800
• 精确质量: 246.08300
• PSA: 53.60000
• LogP: 2.71170
• InChIKey: MRNNJVNMXOZEQC-UHFFFAOYSA-N
• SMILES: c1ccc(-c2csc(N3CCOCC3)n2)cc1

VPC-14228安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302-H319
• 警示性声明: P301 + P312 + P330-P305 + P351 + P338
• 危险品运输编码: NONH for all modes of transport

VPC-14228靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Chemical Probes of Kaposi's Sarcoma Herpes Virus Latent Infection 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：ORF 73 [Human herpesvirus 8 type M] External Id：HMS791

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Inhibition of androgen receptor transcriptional activity in human LNCaP cells after 3... 来源：ChEMBL 靶标：Androgen receptor External Id：CHEMBL3374323

实验名称：NCATS Human Liver Microsomal (HLM) Stability Profiling 来源：NCGC 靶标：N/A External Id：ADME-HLM1

实验名称：Inhibition of androgen receptor in human LNCaP cells assessed as inhibition of prosta... 来源：ChEMBL 靶标：Androgen receptor External Id：CHEMBL3374324

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Inhibition of human androgen receptor Q592D mutant expressed in human PC3 cells asses... 来源：ChEMBL 靶标：Androgen receptor External Id：CHEMBL3374328

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VPC-14228英文别名

• 2-morpholino-5-phenylthiazole
• 2-Morpholinyl-4-phenylthiazol
• 2-Morpholino-4-phenylthiazol
• 2-morpholino-4-phenyl-thiazole
• 4-Phenyl-2-morpholinyl-thiazol