Tubulin polymerization-IN-37

• 常用名: Tubulin polymerization-IN-37
• 英文名: Tubulin polymerization-IN-37
• CAS号: 2011784-92-0
• 分子量: 340.37
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₂₀N₂O₄
• 熔点: N/A
• 闪点: N/A

Tubulin polymerization-IN-37用途

Tubulin聚合-IN-37是一种微管蛋白聚合抑制剂(IC50:2.3μμm)。微管蛋白聚合-IN-37结合微管蛋白的秋水仙碱位点并抑制秋水仙素结合。Tubulin聚合-IN-37可用于癌症研究,如淋巴瘤[1]。

Tubulin polymerization-IN-37名称

• 英文名: Tubulin polymerization-IN-37

Tubulin polymerization-IN-37生物活性

• 描述: Tubulin聚合-IN-37是一种微管蛋白聚合抑制剂(IC50:2.3μμm)。微管蛋白聚合-IN-37结合微管蛋白的秋水仙碱位点并抑制秋水仙素结合。Tubulin聚合-IN-37可用于癌症研究,如淋巴瘤[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
• 靶点实验:

  Tubulin polymerization[1]

• 体外研究: Tubulin聚合-IN-37(化合物2f,1μμm,72 h)抑制50%以下淋巴瘤细胞的增殖[1]。Tubulin聚合-IN-37(50和500 nM,24-72 h)诱导VL51和MINO细胞中的细胞凋亡并阻滞在G2/M期[1]。微管蛋白聚合-IN-37(5μμm)抑制秋水仙素与微管蛋白结合80%[1]。Tubulin聚合-IN-37对MCF-7细胞具有细胞毒性(IC50:0.21μμm)[1]。细胞增殖试验[1]细胞系：VL51、MINO、HBL1、SU-DHL-10细胞。浓度：0～10μμm孵育时间：72h结果：1μm时,细胞增殖抑制率分别为28.1%、8.6%、7.3%、13.8%。IC50s：分别为0.12、0.07、0.08、0.07μμm。细胞周期分析[1]细胞株：VL51和MINO细胞浓度：50和500nM培养时间：24、48和72小时结果：细胞停滞在G2/M期。
• 参考文献:

  [1]. Michael D Wendt, et al. Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas. J Med Chem. 2006 Feb; 49(3): 1165-81.

Tubulin polymerization-IN-37物理化学性质

• 分子式: C₁₉H₂₀N₂O₄
• 分子量: 340.37

Tubulin polymerization-IN-37靶点实验

查看更多实验

实验名称：Cytotoxicity against human M14 cells assessed as growth inhibition after 72 hrs by MT... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3875799

实验名称：Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by M... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3875800

实验名称：Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hr... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3875801

实验名称：Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by MT... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3875802

实验名称：Cytotoxicity against human JR8 cells assessed as growth inhibition after 72 hrs by MT... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3875798

实验名称：Cytotoxicity against human MCF10A cells assessed as growth inhibition after 72 hrs by... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3875807

实验名称：Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by ... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3875803

实验名称：Cytotoxicity against human STO cells assessed as growth inhibition after 72 hrs by MT... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3875804

实验名称：Cytotoxicity against human MP8 cells assessed as growth inhibition after 72 hrs by MT... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3875805

实验名称：Cytotoxicity against human WI38 cells assessed as growth inhibition after 72 hrs by M... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3875806

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