牛蒡子苷

• 常用名: 牛蒡子苷
• 英文名: Arctiin
• CAS号: 20362-31-6
• 分子量: 534.552
• 密度: 1.4±0.1 g/cm3
• 沸点: 756.4±60.0 °C at 760 mmHg
• 分子式: C₂₇H₃₄O₁₁
• 熔点: 109 °C
• 闪点: 250.1±26.4 °C

牛蒡子苷用途

Arctiin(NSC 315527)是植物木酚素,可从牛蒡种子中提取,具有抗癌活性。

牛蒡子苷名称

• 中文名: 牛蒡子苷
• 英文名: Arctiin
• 中文别名: 牛蒡苷

牛蒡子苷生物活性

• 描述: Arctiin(NSC 315527)是植物木酚素,可从牛蒡种子中提取,具有抗癌活性。
• 相关类别:
  信号通路 >> 其他 >> 其他
  天然产物 >> 苯丙酸类
  研究领域 >> 癌症
• 参考文献:

  [1]. Huang DM, et al. Modulation of anti-adhesion molecule MUC-1 is associated with arctiin-induced growth inhibition in PC-3 cells. Prostate. 2004 May 15;59(3):260-7.

  [2]. Knipping K, et al. In vitro and in vivo anti-allergic effects of Arctium lappa L. Exp Biol Med (Maywood). 2008 Nov;233(11):1469-77.

  [3]. Zeng Y, et al. Lack of significant modifying effect of arctiin on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats. Cancer Lett. 2005 May 26;222(2):145-51.

  [4]. Wu JG, et al. Ameliorative effects of arctiin from Arctium lappa on experimental glomerulonephritis in rats. Phytomedicine. 2009 Nov;16(11):1033-41.

  [5]. Ma ST, et al. Effect of arctiin on glomerular filtration barrier damage in STZ-induced diabetic nephropathy rats. Phytother Res. 2013 Oct;27(10):1474-80.

  [6]. Matsuzaki Y, et al. Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression. Oncol Rep. 2008 Mar;19(3):721-7.

牛蒡子苷物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 756.4±60.0 °C at 760 mmHg
• 熔点: 109 °C
• 分子式: C₂₇H₃₄O₁₁
• 分子量: 534.552
• 闪点: 250.1±26.4 °C
• 精确质量: 534.210083
• PSA: 153.37000
• LogP: 0.23
• InChIKey: XOJVHLIYNSOZOO-SWOBOCGESA-N
• SMILES: COc1ccc(CC2COC(=O)C2Cc2ccc(OC3OC(CO)C(O)C(O)C3O)c(OC)c2)cc1OC
• 外观性状: 白色至灰白色固体
• 蒸汽压: 0.0±2.7 mmHg at 25°C
• 折射率: 1.601
• 储存条件: ?20°C

牛蒡子苷安全信息

• 危险品运输编码: NONH for all modes of transport

牛蒡子苷靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Selectivity index, ratio of CC50 for MRC5 cells to IC50 for HCMV 来源：ChEMBL 靶标：N/A External Id：CHEMBL890914

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induc... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL1043932

实验名称：Primary Screen for Target Class Profiling of Small Molecule Inhibitors of Methyltrans... 来源：NCGC External Id：MTASE-p

实验名称：Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve... 来源：NCGC 靶标：N/A External Id：OBG420

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-2C

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-9B

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant ... 来源：NCGC External Id：s-sky_synergy-MV-411_DR-CTG72-MIPE_NPC_NPACT_Kinase-p1

实验名称：HIV Cellular Data 来源：NIAID 靶标：N/A External Id：HIV Cellular Data

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) naive MV4-11 ce... 来源：NCGC External Id：s-sky_synergy-MV-411_N-CTG72-MIPE_NPC_NPACT_Kinase-p1

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牛蒡子苷英文别名

• MFCD00870630
• Arctiin (8CI)
• 4-{[(3R,4R)-4-(3,4-Dimethoxybenzyl)-2-oxotetrahydro-3-furanyl]methyl}-2-methoxyphenyl β-D-glucopyranoside
• Arctigenin-4-glucoside
• Arctin
• Arctlin
• Arctiin
• 4-{[(3R,4R)-4-(3,4-Dimethoxybenzyl)-2-oxotetrahydrofuran-3-yl]methyl}-2-methoxyphenyl β-D-glucopyranoside
• Great Burdock Root Extract
• NSC 315527
• Acrctiin