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牛蒡子苷

牛蒡子苷用途

Arctiin(NSC 315527)是植物木酚素,可从牛蒡种子中提取,具有抗癌活性。

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牛蒡子苷名称

[ CAS 号 ]:
20362-31-6

[ 中文名 ]:
牛蒡子苷

[ 英文名 ]:
Arctiin

[中文别名 ]:

牛蒡苷

[英文别名 ]:

MFCD00870630
Arctiin (8CI)
Arctigenin-4-glucoside
Arctin
Arctlin
Arctiin
Great Burdock Root Extract
NSC 315527
Acrctiin

牛蒡子苷生物活性

[ 描述 ]:

Arctiin(NSC 315527)是植物木酚素,可从牛蒡种子中提取,具有抗癌活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

天然产物 >> 苯丙酸类

研究领域 >> 癌症

[参考文献]

[1]. Huang DM, et al. Modulation of anti-adhesion molecule MUC-1 is associated with arctiin-induced growth inhibition in PC-3 cells. Prostate. 2004 May 15;59(3):260-7.

[2]. Knipping K, et al. In vitro and in vivo anti-allergic effects of Arctium lappa L. Exp Biol Med (Maywood). 2008 Nov;233(11):1469-77.

[3]. Zeng Y, et al. Lack of significant modifying effect of arctiin on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats. Cancer Lett. 2005 May 26;222(2):145-51.

[4]. Wu JG, et al. Ameliorative effects of arctiin from Arctium lappa on experimental glomerulonephritis in rats. Phytomedicine. 2009 Nov;16(11):1033-41.

[5]. Ma ST, et al. Effect of arctiin on glomerular filtration barrier damage in STZ-induced diabetic nephropathy rats. Phytother Res. 2013 Oct;27(10):1474-80.

[6]. Matsuzaki Y, et al. Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression. Oncol Rep. 2008 Mar;19(3):721-7.

[相关活性小分子]

牛蒡子苷物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
756.4±60.0 °C at 760 mmHg

[ 熔点 ]:
109 °C

[ 分子式 ]:
C₂₇H₃₄O₁₁

[ 分子量 ]:
534.552

[ 闪点 ]:
250.1±26.4 °C

[ 精确质量 ]:
534.210083

[ PSA ]:
153.37000

[ LogP ]:
0.23

[ 外观性状 ]:
白色至灰白色固体

[ 蒸汽压 ]:
0.0±2.7 mmHg at 25°C

[ 折射率 ]:
1.601

[ 储存条件 ]:
?20°C

牛蒡子苷安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

牛蒡子苷文献

Plasma pharmacokinetics and tissue distribution of arctiin and its main metabolite in rats by HPLC-UV and LC-MS.

Planta Med. 78(8) , 800-6, (2012)

The pharmacokinetic profile of arctiin, the major active lignan in fruits of Arctium lappa L., was investigated. Its main meta"bolite arctigenin was identified by an LC-MS method, and an HPLC-UV techn...

Simultaneous determination of arctiin and its metabolites in rat urine and feces by HPLC.

Fitoterapia 86 , 6-12, (2013)

Arctiin, an important lignan compound in Fructus Arctii, has been reported to possess various kinds of bioactivities. Previous studies on the pharmacokinetic of arctiin after oral administration showe...

Effects of arctiin on streptozotocin-induced diabetic retinopathy in Sprague-Dawley rats.

Planta Med. 78(12) , 1317-23, (2012)

Diabetic retinopathy is one of the most common and severe complications of diabetes mellitus. Arctiin, a bioactive compound isolated from the dry seeds of Arctium lappa L., has been reported to have a...

更多文献

牛蒡子苷

牛蒡子苷用途

牛蒡子苷名称

牛蒡子苷生物活性

牛蒡子苷物理化学性质

牛蒡子苷安全信息

牛蒡子苷文献

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