LAU159

• 常用名: LAU159
• 英文名: LAU159
• CAS号: 2055050-87-6
• 分子量: 325.749
• 密度: 1.5±0.1 g/cm3
• 沸点: 473.8±55.0 °C at 760 mmHg
• 分子式: C₁₇H₁₂ClN₃O₂
• 熔点: N/A
• 闪点: 240.3±31.5 °C

LAU159用途

LAU159 是 α1β3 GABA(A) 受体的功能选择性正调节剂,EC50为 2.2 μM。

LAU159名称

• 英文名: LAU159

LAU159生物活性

• 描述: LAU159 是 α1β3 GABA(A) 受体的功能选择性正调节剂,EC50为 2.2 μM。
• 相关类别:
  信号通路 >> 跨膜转运 >> GABA受体
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> GABA受体
• 靶点实验:

  EC50: 2.2 μM (α1β3 GABA(A) receptor)[1]

• 参考文献:

  [1]. Varagic Z, et al. Identification of novel positive allosteric modulators and null modulators at the GABAA receptor α+β- interface. Br J Pharmacol. 2013 May;169(2):371-83.

LAU159物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 473.8±55.0 °C at 760 mmHg
• 分子式: C₁₇H₁₂ClN₃O₂
• 分子量: 325.749
• 闪点: 240.3±31.5 °C
• 精确质量: 325.061798
• LogP: 3.16
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.706
• 储存条件: -20°C，密闭，干燥

LAU159靶点实验

查看更多实验

实验名称：Displacement of [3H]-dofetilide from human ERG expressed in HEK cell membranes at >10... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL4037910

实验名称：Aqueous solubility of the compound in DI water at pH 7 after 2 hrs by LC-MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4037810

实验名称：Solubility of the compound in 0.01M HCl at pH 2 after 2 hrs by LC-MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4037811

实验名称：Positive allosteric modulation of GABA-A receptor alpha1beta3gamma2 (unknown origin) ... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit gamma-2 External Id：CHEMBL4037820

实验名称：Neurotoxicity in Swiss Webster mouse assessed as induction of motor impairment at 40 ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4037852

实验名称：Positive allosteric modulation of GABA-A receptor alpha6beta3gamma2 (unknown origin) ... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-6 External Id：CHEMBL4037831

实验名称：Half life in mouse liver microsomes at 10 uM by LC-MS/MS analysis 来源：ChEMBL 靶标：Liver External Id：CHEMBL4037808

实验名称：Positive allosteric modulation of GABA-A receptor alpha4beta3gamma2 (unknown origin) ... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-4 External Id：CHEMBL4037840

实验名称：Positive allosteric modulation of GABA-A receptor alpha5beta3gamma2 (unknown origin) ... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit gamma-2 External Id：CHEMBL4037841

实验名称：Metabolic stability in mouse liver microsomes assessed as parent compound remaining a... 来源：ChEMBL 靶标：Liver External Id：CHEMBL4037809

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LAU159英文别名

• 8-Chloro-2-(3-methoxyphenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one