Dyrk1A-IN-4

• 常用名: Dyrk1A-IN-4
• 英文名: Dyrk1A-IN-4
• CAS号: 2091883-59-7
• 分子量: 322.29
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₃F₃N₆
• 熔点: N/A
• 闪点: N/A

Dyrk1A-IN-4用途

Dyrk1A-IN-4(化合物48)是一种有效的口服活性Dyrk1A和DYRK2抑制剂,IC50s分别为2 nM和6 nM。Dyrk1A-IN-4具有抗癌作用[1]。

Dyrk1A-IN-4名称

• 英文名: Dyrk1A-IN-4

Dyrk1A-IN-4生物活性

• 描述: Dyrk1A-IN-4(化合物48)是一种有效的口服活性Dyrk1A和DYRK2抑制剂,IC50s分别为2 nM和6 nM。Dyrk1A-IN-4具有抗癌作用[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白酪氨酸激酶 >> DYRK
• 靶点实验:

  DYRK1A:2 nM (IC50)

  DYRK2:6 nM (IC50)

• 参考文献:

  [1]. Csaba Weber, et al. Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors. J Med Chem. 2021 May 27;64(10):6745-6764.

Dyrk1A-IN-4物理化学性质

• 分子式: C₁₄H₁₃F₃N₆
• 分子量: 322.29

Dyrk1A-IN-4靶点实验

查看更多实验

实验名称：Antitumor activity against human RS4-11 cells xenografted in BALB/c nu/nu mouse asses... 来源：ChEMBL 靶标：RS4-11 External Id：CHEMBL5042826

实验名称：Inhibition of recombinant human CK1epsilon expressed in Sf9 insect cells incubated fo... 来源：ChEMBL 靶标：Casein kinase I isoform epsilon External Id：CHEMBL5251364

实验名称：Inhibition of recombinant human CDK5/p25 expressed in Sf9 insect cells incubated for ... 来源：ChEMBL 靶标：Cyclin-dependent kinase 5 External Id：CHEMBL5251363

实验名称：Inhibition of recombinant human CLK2 expressed in Sf9 insect cells incubated for 60 m... 来源：ChEMBL 靶标：Dual specificity protein kinase CLK2 External Id：CHEMBL5251366

实验名称：Inhibition of recombinant human CLK1 expressed in Sf9 insect cells incubated for 60 m... 来源：ChEMBL 靶标：Dual specificity protein kinase CLK1 External Id：CHEMBL5251365

实验名称：Antitumor activity against human RS4-11 cells xenografted in BALB/c nu/nu mouse reduc... 来源：ChEMBL 靶标：RS4-11 External Id：CHEMBL5042827

实验名称：Inhibition of wild type full length DYRK1A (unknown origin) in human U2OS cells asses... 来源：ChEMBL 靶标：Dual specificity tyrosine-phosphorylation-regulated kinase 1A External Id：CHEMBL5042809

实验名称：Inhibition of DYRK2 (unknown origin) using Ulight-MBP as substrate and ATP as co-subs... 来源：ChEMBL 靶标：Dual specificity tyrosine-phosphorylation-regulated kinase 2 External Id：CHEMBL5042808

实验名称：Inhibition of CDK9 (unknown origin) using Ulight-MBP as substrate and ATP as co-subst... 来源：ChEMBL 靶标：Cyclin-dependent kinase 9 External Id：CHEMBL5042807

实验名称：Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-sub... 来源：ChEMBL 靶标：Dual specificity tyrosine-phosphorylation-regulated kinase 1A External Id：CHEMBL5042806

共33条，当前第1页，共4页

1

2

3

4