SB 271046盐酸盐

• 常用名: SB 271046盐酸盐
• 英文名: SB 271046 (Hydrochloride)
• CAS号: 209481-24-3
• 分子量: 488.45
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₃Cl₂N₃O₃S₂
• 熔点: N/A
• 闪点: N/A

SB 271046盐酸盐用途

SB271046盐酸盐是口服活性的5-HT6受体拮抗剂，pKi为8.9。

SB 271046盐酸盐名称

• 中文名: SB 271046盐酸盐
• 英文名: UNII:5346058Q7S

SB 271046盐酸盐生物活性

• 描述: SB271046盐酸盐是口服活性的5-HT6受体拮抗剂,pKi为8.9。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Routledge C, et al. Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonist. Br J Pharmacol. 2000 Aug;130(7):1606-12.

  [2]. Bromidge SM, et al. 5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor antagonist. J Med Chem. 1999 Jan 28;42(2):202-5.

  [3]. Dawson LA, et al. The 5-HT(6) receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus. Neuropsychopharmacology. 2001 Nov;25(5):662-8.

SB 271046盐酸盐物理化学性质

• 分子式: C₂₀H₂₃Cl₂N₃O₃S₂
• 分子量: 488.45
• InChIKey: RMXZRJYGJMSDQK-UHFFFAOYSA-N
• SMILES: COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCNCC1.Cl
• 外观性状: 粉末
• 储存条件: -20℃

SB 271046盐酸盐安全信息

• 危险品运输编码: NONH for all modes of transport

SB 271046盐酸盐靶点实验

查看更多实验

实验名称：This assay (PMID: 37558952) monitors the impact of a chemical compound on general aut... 来源：ChEMBL 靶标：TERT-RPE1 External Id：CHEMBL5724699

实验名称：This assay (PMID: 37558952) monitors the impact of a chemical compound on general aut... 来源：ChEMBL 靶标：U2OS External Id：CHEMBL5724701

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

实验名称：This assay (PMID: 37558952) monitors the impact of a chemical compound on ER-phagy fl... 来源：ChEMBL 靶标：U2OS External Id：CHEMBL5724700

实验名称：Thermal Shift Assay. Domain: start/stop: M1-K294 来源：ChEMBL 靶标：Casein kinase I isoform delta External Id：CHEMBL5063812

实验名称：Thermal Shift Assay. Domain: start/stop: M26-R383 来源：ChEMBL 靶标：Glycogen synthase kinase-3 beta External Id：CHEMBL5065589

实验名称：Thermal Shift Assay. Domain: start/stop: S229-K512 来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1 External Id：CHEMBL5060015

实验名称：GPCR beta-arrestin recruitment assay with target: FPR2 Assay Type: PRESTO-Tango Conce... 来源：ChEMBL 靶标：N-formyl peptide receptor 2 External Id：CHEMBL5209827

实验名称：PDSP Secondary Binding target: ADRA2A - Compounds are tested at 10 uM concentration, ... 来源：ChEMBL 靶标：Alpha-2A adrenergic receptor External Id：CHEMBL5442194

实验名称：GPCR beta-arrestin recruitment assay with target: FPR2 Assay Type: PRESTO-Tango Conce... 来源：ChEMBL 靶标：N-formyl peptide receptor 2 External Id：CHEMBL5209826

共141条，当前第1页，共15页

1

2

3

4

5

SB 271046盐酸盐英文别名

• 2,6-Piperazinedione, 4-[(1S)-2-(3,5-dioxo-1-piperazinyl)-1-methylethyl]-, hydrochloride (1:1)
• 4,4'-(2S)-Propan-1,2-diyldipiperazin-2,6-dionhydrochlorid
• 4,4'-(2S)-propane-1,2-diyldipipérazine-2,6-dione chlorhydrate
• (S)-4,4'-(1-Methyl-1,2-ethanediyl)bis-2,6-piperazinedionehydrochloride
• Dexrazoxane hydrochloride
• 2,6-Piperazinedione, 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-, hydrochloride (1:1)
• 4,4'-[(2S)-1,2-Propanediyl]di(2,6-piperazinedione) hydrochloride (1:1)
• 2,6-piperazinedione, 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-, monohydrochloride
• 4,4'-(2S)-Propane-1,2-diyldipiperazine-2,6-dione hydrochloride (1:1)
• Dexrazoxane HCl
• UNII:5346058Q7S
• SB 271046 (Hydrochloride)