MELK-IN-1

• 常用名: MELK-IN-1
• 英文名: MELK inhibitor 17
• CAS号: 2095596-44-2
• 分子量: 539.62
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₁H₃₃N₅O₄
• 熔点: N/A
• 闪点: N/A

MELK-IN-1用途

MELK-IN-1是母体胚胎亮氨酸拉链激酶 (MELK)的有效抑制剂,IC50 和 Ki 分别为3 nM和0.39 nM。

MELK-IN-1名称

• 中文名: MELK-IN-1
• 英文名: MELK-IN-1

MELK-IN-1生物活性

• 描述: MELK-IN-1是母体胚胎亮氨酸拉链激酶 (MELK)的有效抑制剂,IC50 和 Ki 分别为3 nM和0.39 nM。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> MELK
• 靶点实验:

  IC50: 3 nM (MELK) Ki: 0.39 nM (MELK)[1]

• 参考文献:

  [1]. Edupuganti R, et al. Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth. Bioorg Med Chem. 2017 May 1;25(9):2609-2616.

MELK-IN-1物理化学性质

• 分子式: C₃₁H₃₃N₅O₄
• 分子量: 539.62
• InChIKey: XIMRJNBUWJTLAL-UHFFFAOYSA-N
• SMILES: COC(=O)c1ccc2[nH]c(O)c(C(=Nc3ccc(N(C)C(=O)CN4CCN(C)CC4)cc3)c3ccccc3)c2c1

MELK-IN-1靶点实验

查看更多实验

实验名称：Selectivity ratio of Ki for ERK2 (unknown origin) to Ki for His6-tagged MELK catalyti... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4029829

实验名称：Selectivity ratio of Ki for CAMKK2 (unknown origin) to Ki for His6-tagged MELK cataly... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4029830

实验名称：Selectivity ratio of Ki for full length recombinant human N-terminal GST-tagged NUAK1... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4029827

实验名称：Selectivity ratio of Ki for full length recombinant human N-terminal His-tagged CHK1 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4029828

实验名称：Selectivity ratio of Ki for AMPK (unknown origin) to Ki for His6-tagged MELK catalyti... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4029826

实验名称：Antiproliferative activity against human MCF10A cells at 10 uM after 72 hrs by CellTi... 来源：ChEMBL 靶标：MCF-10A External Id：CHEMBL4029835

实验名称：Antiproliferative activity against human BT549 cells up to 20 uM after 72 hrs by Cell... 来源：ChEMBL 靶标：BT-549 External Id：CHEMBL4029833

实验名称：Antiproliferative activity against human SUM159 cells up to 20 uM after 72 hrs by Cel... 来源：ChEMBL 靶标：SUM-159-PT External Id：CHEMBL4029834

实验名称：Inhibition of MELK in human HCC70 cells assessed as reduction in Mcl-1 expression up ... 来源：ChEMBL 靶标：Maternal embryonic leucine zipper kinase External Id：CHEMBL4029831

实验名称：Antiproliferative activity against human HCC70 cells up to 20 uM after 72 hrs by Cell... 来源：ChEMBL 靶标：HCC70 External Id：CHEMBL4029832

共14条，当前第1页，共2页

1

2