para-amino-Blebbistatin

• 常用名: para-amino-Blebbistatin
• 英文名: para-amino-Blebbistatin
• CAS号: 2097734-03-5
• 分子量: 307.346
• 密度: 1.4±0.1 g/cm3
• 沸点: 571.3±60.0 °C at 760 mmHg
• 分子式: C₁₈H₁₇N₃O₂
• 熔点: N/A
• 闪点: 299.3±32.9 °C

para-amino-Blebbistatin用途

对氨基blebbistatin是一种高度水溶性、非荧光和光稳定性的blebbistantin的C15氨基取代衍生物；在体外和体内抑制各种(肌球蛋白II)异构体。

para-amino-Blebbistatin名称

• 英文名: para-amino-Blebbistatin

para-amino-Blebbistatin生物活性

• 描述: 对氨基blebbistatin是一种高度水溶性、非荧光和光稳定性的blebbistantin的C15氨基取代衍生物；在体外和体内抑制各种(肌球蛋白II)异构体。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 细胞骨架 >> 肌球蛋白
  研究领域 >> 神经疾病
• 靶点实验:

  Myosin II[1]

• 参考文献:

  [1]. Várkuti BH, et al. A highly soluble, non-phototoxic, non-fluorescent blebbistatin derivative. Sci Rep. 2016 May 31;6:26141.

  [2]. Képiró M, et al. para-Nitroblebbistatin, the non-cytotoxic and photostable myosin II inhibitor. Angew Chem Int Ed Engl. 2014 Jul 28;53(31):8211-5.

para-amino-Blebbistatin物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 571.3±60.0 °C at 760 mmHg
• 分子式: C₁₈H₁₇N₃O₂
• 分子量: 307.346
• 闪点: 299.3±32.9 °C
• 精确质量: 307.132080
• LogP: 0.34
• InChIKey: LYWLZINJPRNWFF-GOSISDBHSA-N
• SMILES: Cc1ccc2c(c1)C(=O)C1(O)CCN(c3ccc(N)cc3)C1=N2
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.715
• 储存条件: 2-8°C

para-amino-Blebbistatin靶点实验

查看更多实验

实验名称：Apparent permeability from apical to basolateral side in human Caco2 cells at 10 uM a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4138912

实验名称：Apparent permeability from basolateral to apical side in human Caco2 cells at 10 uM a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4138913

实验名称：Induction of multinucleation in human HeLa cells assessed as increase in live nuclei ... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL5541936

实验名称：Potency index, ratio of (S)-blebbistatin (S)-1 IC50 to compound IC50 for inhibition o... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4138910

实验名称：Aqueous solubility at steady-state in pH 7.4 PBS at 200 uM after 24 hrs by HPLC metho... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4138911

实验名称：Binding affinity to dephosphorylated human CITK kinase domain (Met1 to Ala449) purifi... 来源：ChEMBL 靶标：Citron Rho-interacting kinase External Id：CHEMBL5541923

实验名称：Binding affinity to hyper-phosphorylated human CITK kinase domain (Met1 to Ala449) pu... 来源：ChEMBL 靶标：Citron Rho-interacting kinase External Id：CHEMBL5541925

实验名称：Photostability of the compound in DMSO/H20 (1:1) solvent assessed as half life for co... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4138918

实验名称：Inhibition of Non-muscle myosin IIB in African green monkey COS-7 cells assessed as i... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5355884

实验名称：Inhibition of full length chicken phosphorylated myosin 2 smooth muscle isoform deriv... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5355881

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para-amino-Blebbistatin英文别名

• (3aS)-1-(4-Aminophenyl)-3a-hydroxy-6-methyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
• para-amino-Blebbistatin