AZ3451

• 常用名: AZ3451
• 英文名: AZ 3451
• CAS号: 2100284-59-9
• 分子量: 571.46
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₀H₂₇BrN₄O₃
• 熔点: N/A
• 闪点: N/A

AZ3451用途

AZ3451是蛋白酶激活受体-2 (protease-activated receptor-2 (PAR2)) 拮抗剂。

AZ3451名称

• 中文名: AZ3451
• 英文名: AZ3451

AZ3451生物活性

• 描述: AZ3451是蛋白酶激活受体-2 (protease-activated receptor-2 (PAR2)) 拮抗剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 蛋白酶激活受体(PAR)
  研究领域 >> 炎症/免疫
• 靶点实验:

  Protease-activated receptor-2[1]

• 体外研究: 拮抗剂AZ3451与蛋白酶激活受体2的螺旋束外的远端变构位点结合.AZ3451是高度亲脂性的,其与膜内结合袋的疏水性质一致。拮抗剂结合可防止受体激活和信号传导所需的结构重排[1]。
• 参考文献:

  [1]. Cheng RKY, et al. Structural insight into allosteric modulation of protease-activated receptor 2. Nature. 2017 May 4;545(7652):112-115.

AZ3451物理化学性质

• 分子式: C₃₀H₂₇BrN₄O₃
• 分子量: 571.46
• InChIKey: FJAOGFGHTPYADT-SFHVURJKSA-N
• SMILES: CC(C1CCCCC1)n1c(-c2cc3c(cc2Br)OCO3)nc2cc(C(=O)Nc3ccc(C#N)cc3)ccc21
• 储存条件: 2-8℃

AZ3451靶点实验

查看更多实验

实验名称：IC50 for antiviral activity against SARS-CoV-2 in the Vero E6 cell line at 48 h by im... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303083

实验名称：Human PAR2 (Proteinase-activated receptors) 来源：IUPHAR-DB 靶标：PAR2 (Proteinase-activated receptors) [Homo sapiens] External Id：348_Human

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Selectivity ratio: ratio of AUC (viral infection %) of SARS-CoV-2 in the Vero E6 cell... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4303091

实验名称：Overall antiviral activity against SARS-CoV-2 (isolate France/IDF0372/2020) in the Ve... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303092

实验名称：Cytotoxicity of compound against Vero E6 cells by MTT assay. 来源：ChEMBL 靶标：Vero C1008 External Id：CHEMBL4303086

实验名称：AUC (viral infection %) for SARS-CoV-2 in the Vero E6 cell line at 48 h by immunofluo... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303085

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：AUC (cytotoxicity %) of compound against Vero E6 cells by MTT assay. 来源：ChEMBL 靶标：Vero C1008 External Id：CHEMBL4303089

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