GW274150

• 常用名: GW274150
• 英文名: GW274150
• CAS号: 210354-22-6
• 分子量: 219.30
• 密度: N/A
• 沸点: N/A
• 分子式: C₈H₁₇N₃O₂S
• 熔点: N/A
• 闪点: N/A

GW274150用途

GW274150是一种新型的NADPH依赖性的iNOS抑制剂。

GW274150名称

• 中文名: GW274150
• 英文名: 4-(2-acetamidoethylsulfanyl)-2-aminobutanoic acid

GW274150生物活性

• 描述: GW274150是一种新型的NADPH依赖性的iNOS抑制剂。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 一氧化氮合酶
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Broom L, et al. Neuroprotection by the selective iNOS inhibitor GW274150 in a model of Parkinson disease. Free Radic Biol Med. 2011 Mar 1;50(5):633-40.

  [2]. Seymour M, et al. Ultrasonographic measures of synovitis in an early phase clinical trial: a double-blind, randomised, placebo and comparator controlled phase IIa trial of GW274150 (a selective inducible nitric oxide synthase inhibitor) in rheumatoid arthritis. Clin Exp Rheumatol. 2012 Mar-Apr;30(2):254-61.

GW274150物理化学性质

• 分子式: C₈H₁₇N₃O₂S
• 分子量: 219.30
• PSA: 121.21000
• LogP: 1.19830
• InChIKey: MOLOJNHYNHBPCW-ZETCQYMHSA-N
• SMILES: CC(N)=NCCSCCC(N)C(=O)O
• 储存条件: 2-8℃

GW274150靶点实验

查看更多实验

实验名称：Inhibition of human eNOS expressed in insect SF9 cells at 10 uM after 1 hr 来源：ChEMBL 靶标：Nitric oxide synthase, endothelial External Id：CHEMBL946896

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：In vitro inhibition of human Inducible nitric oxide synthase. 来源：ChEMBL 靶标：Nitric oxide synthase, inducible External Id：CHEMBL701150

实验名称：In vitro inhibition of human neuronal nitric oxide synthase. 来源：ChEMBL 靶标：Nitric oxide synthase, brain External Id：CHEMBL751656

实验名称：In vitro inhibition of human endothelial nitric oxide synthase. 来源：ChEMBL 靶标：Nitric oxide synthase, endothelial External Id：CHEMBL678077

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Ratio of Endothelial Nitric Oxide Synthase to Inducible nitric oxide synthase 来源：ChEMBL 靶标：Nitric oxide synthase (inducible and endothelial) External Id：CHEMBL675570

实验名称：Inhibition of human recombinant eNOS by microtiter plate assay 来源：ChEMBL 靶标：Nitric oxide synthase, endothelial External Id：CHEMBL1786327

实验名称：Inhibition of human recombinant iNOS by microtiter plate assay 来源：ChEMBL 靶标：Nitric oxide synthase, inducible External Id：CHEMBL1786326

实验名称：Selectivity index, ratio of IC50 for human recombinant iNOS to IC50 for human recombi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1786329

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GW274150英文别名

• GW274150