5-HT2C agonist-3

• 常用名: 5-HT2C agonist-3
• 英文名: 5-HT2C agonist-3
• CAS号: 2104810-18-4
• 分子量: 351.84
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₂₃ClFNO₂
• 熔点: N/A
• 闪点: N/A

5-HT2C agonist-3用途

5-HT2C激动剂-3((+)-19)是选择性5-HT2C兴奋剂(EC50:24nM,Ki:78nM)。5-HT2C激动剂-3具有抗精神病药物样活性。5-HT2C激动剂-3阻断苯丙胺诱导的多动症[1]。

5-HT2C agonist-3名称

• 英文名: 5-HT2C agonist-3

5-HT2C agonist-3生物活性

• 描述: 5-HT2C激动剂-3((+)-19)是选择性5-HT2C兴奋剂(EC50:24nM,Ki:78nM)。5-HT2C激动剂-3具有抗精神病药物样活性。5-HT2C激动剂-3阻断苯丙胺诱导的多动症[1]。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 靶点实验:

  EC50: 24 nM, Ki: 78 nM (5-HT2C)[1]

• 参考文献:

  [1]. Guiping Zhang, et al. Discovery of N-Substituted (2-Phenylcyclopropyl)methylamines as Functionally Selective Serotonin 2C Receptor Agonists for Potential Use as Antipsychotic Medications. J. Med. Chem. 2017, 60, 14, 6273–6288.

5-HT2C agonist-3物理化学性质

• 分子式: C₁₉H₂₃ClFNO₂
• 分子量: 351.84

5-HT2C agonist-3靶点实验

查看更多实验

实验名称：Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed a... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2B External Id：CHEMBL4013759

实验名称：Agonist activity at human 5-HT2A receptor expressed in Flp-IN HEK293 cells assessed a... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2A External Id：CHEMBL4013760

实验名称：Agonist activity at tTA containing TEV cleavage site-fused 5-HT2C-INI receptor isofor... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2C External Id：CHEMBL4013787

实验名称：Half life in mouse hepatocytes at 1 uM assessed per million cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL4013755

实验名称：Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cell... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2C External Id：CHEMBL4013756

实验名称：Agonist activity at human 5-HT2A receptor expressed in Flp-IN HEK293 cells assessed a... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2A External Id：CHEMBL4013785

实验名称：Half life in human hepatocytes at 1 uM assessed per million cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL4013754

实验名称：Ratio of Emax to EC50 for tTA containing TEV cleavage site-fused 5-HT2C-INI receptor ... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2C External Id：CHEMBL4013765

实验名称：Ratio of Emax to EC50 for human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK29... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2C External Id：CHEMBL4013764

实验名称：Agonist activity at tTA containing TEV cleavage site-fused 5-HT2C-INI receptor isofor... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2C External Id：CHEMBL4013762

共21条，当前第1页，共3页

1

2

3