石蒜胺

• 常用名: 石蒜胺
• 英文名: Lycoramine free base
• CAS号: 21133-52-8
• 分子量: 289.36900
• 密度: 1.25
• 沸点: 436.4ºC at 760mmHg
• 分子式: C₁₇H₂₃NO₃
• 熔点: 122-124ºC
• 闪点: 217.7ºC

石蒜胺用途

Lycoramine 是一种从 Lycoris radiate 中分离出的加兰他敏的二氢衍生物。Lycoramine 是一种有效的乙酰胆碱酯酶 (AChE) 抑制剂。

石蒜胺名称

• 中文名: 二氢加兰他敏
• 英文名: Lycoramine
• 中文别名: 石蒜胺

石蒜胺生物活性

• 描述: Lycoramine 是一种从 Lycoris radiate 中分离出的加兰他敏的二氢衍生物。Lycoramine 是一种有效的乙酰胆碱酯酶 (AChE) 抑制剂。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> 疼痛
• 靶点实验:

  AChE[1]

• 参考文献:

  [1]. Yuan Y, et, al. Online acetylcholinesterase inhibition evaluation by high-performance liquid chromatography-mass spectrometry hyphenated with an immobilized enzyme reactor. J Chromatogr A. 2020 Jan 4; 1609:460506.

  [2]. IRWIN RL, et, al. Cholinesterase inhibition by galanthamine and lycoramine. Biochem Pharmacol. 1960 May; 3:147-8.

石蒜胺物理化学性质

• 密度: 1.25
• 沸点: 436.4ºC at 760mmHg
• 熔点: 122-124ºC
• 分子式: C₁₇H₂₃NO₃
• 分子量: 289.36900
• 闪点: 217.7ºC
• 精确质量: 289.16800
• PSA: 41.93000
• LogP: 2.01220
• InChIKey: GJRMHIXYLGOZSE-JDFRZJQESA-N
• SMILES: COc1ccc2c3c1OC1CC(O)CCC31CCN(C)C2
• 外观性状: 白色粉末
• 蒸汽压: 2.17E-08mmHg at 25°C
• 折射率: 1.614
• 储存条件: 2-8°C

石蒜胺靶点实验

查看更多实验

实验名称：Cytotoxicity against human Jurkat cells assessed as cell growth at 10 uM measured aft... 来源：ChEMBL 靶标：Jurkat External Id：CHEMBL5589474

实验名称：Cytotoxicity against human MOLT-4 cells assessed as cell growth at 10 uM measured aft... 来源：ChEMBL 靶标：MOLT-4 External Id：CHEMBL5589475

实验名称：Cytotoxicity against human A549 cells assessed as cell growth at 10 uM measured after... 来源：ChEMBL 靶标：A549 External Id：CHEMBL5589476

实验名称：Cytotoxicity against human HT-29 cells assessed as cell growth at 10 uM measured afte... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL5589477

实验名称：Cytotoxicity against human PANC-1 cells assessed as cell growth at 10 uM measured aft... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL5589478

实验名称：Cytotoxicity against human A2780 cells assessed as cell growth at 10 uM measured afte... 来源：ChEMBL 靶标：A2780 External Id：CHEMBL5589479

实验名称：Cytotoxicity against human HeLa cells assessed as cell growth at 10 uM measured after... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL5589480

实验名称：Cytotoxicity against human MCF7 cells assessed as cell growth at 10 uM measured after... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL5589481

实验名称：Cytotoxicity against human SAOS-2 cells assessed as cell growth at 10 uM measured aft... 来源：ChEMBL 靶标：SAOS-2 External Id：CHEMBL5589482

实验名称：Cytotoxicity against human MRC5 cells assessed as cell growth at 10 uM measured after... 来源：ChEMBL 靶标：MRC5 External Id：CHEMBL5589483

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石蒜胺英文别名

• (+-)-Lycoramin
• Dihydrogalanthamine
• (4aS,6S,8aR)-4a,5,7,8,9,10,11,12-Octahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol
• 1,2-Dihydrogalanthamine
• UNII-TAG8LU84K2
• (-)-lycoramine