21133-52-8

• 常用中文名：石蒜胺
• 常用英文名：Lycoramine free base
• CAS号：21133-52-8
• 分子式：C₁₇H₂₃NO₃
• 分子量：289.36900
• 相关类别： 原料药 神经系统用药 拟胆碱药
• 发布时间：2018-07-30 16:34:16
• 更新时间：2026-07-06 09:10:11
• Lycoramine 是一种从 Lycoris radiate 中分离出的加兰他敏的二氢衍生物。Lycoramine 是一种有效的乙酰胆碱酯酶 (AChE) 抑制剂。

名称

• 中文名: 二氢加兰他敏
• 英文名: Lycoramine
• 中文别名: 加兰他敏杂质03; 氢溴酸加兰他敏杂质Ⅰ(氢溴酸力克拉敏)11-甲基-3-甲氧基-4A,5,7,8,9,10,11,12-八氢-6H-苯并呋喃并[3A,3,2-EF]苯并氮杂-6-醇; 氢溴酸加兰他敏杂质C; 氢溴化物加兰他敏杂质C; 加兰他敏杂质C(二氢加兰他敏); 氢溴酸加兰他敏杂质Ⅰ（氢溴酸力克拉敏）11-甲基-3-甲氧基-4a，5，7，8，9，10，11，12-八氢-6H-苯并呋喃并[3a，3，2-ef]苯并氮杂-6-醇; 氢溴酸力克拉敏; 二氢加兰他敏,10 MM DMSO 溶液; 加兰他敏杂质C
• 英文别名: (-)-lycoramine; (4aS,6S,8aS)-4a,5,7,8,9,10,11,12-Octahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef]benzazin-6-ol; Galantamine hydrobromide Impurity C; Galantamine Impurity 3（Galantamine Impurity C）; Lycoramine,AChE,Inhibitor,radiate,dihydro-derivative,inhibit,galanthamine,acetylcholinesterase,Lycoris,Cholinesterase (ChE); (+-)-Lycoramin; Galanthamine, 1,2-dihydro; (4aS,8aS)-4a,5,7,8,9,10,11,12-Octahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef]benzazin-6β-ol; LycoraMine HydrobroMide; Galantamine Impurity C (Dihydro Galantamine); (4aS,8aS)-3-Methoxy-11-methyl-4aα,5,7,8,9,10,11,12-octahydro-6H-benzofuro[3a,3,2-ef]benzoazine-6β-ol; Galantamine impurity C; (4aS,6S,8aR)-4a,5,7,8,9,10,11,12-Octahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol; Dihydrogalanthamine //BP; Lycoramine, 10 mM in DMSO; (4aS,6S,8); (4aS,6S,8-3-methoxy-11-methyl-5,6,7,8,9,10,11,12- octahydro-4aH-benzofuro[3a,3,2-ef]benzazin-6-ol; Galantamine Impurity C (Dihydro Galantamine/ Lycoramine); (8aS)-3-Methoxy-5,6,7,8,9,10,11,12-octahydro-11-methyl-4aαH-benzofuro[3a,3,2-ef]benzazine-6β-ol; Lycoramin; 6H-Benzofuro[3a,3,2-ef]benzazin-6-ol, 4a,5,7,8,9,10,11,12-octahydro-3-methoxy-11-methyl-,(4aS,6S,8); Galanthamine, dihydro; Galantamine hydrobromide Imp. C: (4aS,6S,8-3-methoxy-11-methyl-5,6,7,8,9,10,11,12-octahydro- 4aH-benzofuro[3a,3,2-ef]benzazin-6-ol (dihydrogalantamine); Galanthamine Impurity C; Galantamine Hydrobromide Impurity Ⅰ:Galantamine Impurity C (Dihydro Galantamine)(4aS,6S,8-4a,5,7,8,9,10,11,12-Octahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef]benzazin-6-ol; 1,2-Dihydrogalanthamine; UNII-TAG8LU84K2; Dihydrogalanthamine

物化性质

• 密度: 1.25
• 沸点: 436.4ºC at 760mmHg
• 熔点: 122-124ºC
• 分子式: C₁₇H₂₃NO₃
• 分子量: 289.36900
• 闪点: 217.7ºC
• 精确质量: 289.16800
• PSA: 41.93000
• LogP: 2.01220
• 外观性状: 白色粉末
• 蒸汽压: 2.17E-08mmHg at 25°C
• 折射率: 1.614
• 储存条件: 2-8°C

生物活性

• 描述: Lycoramine 是一种从 Lycoris radiate 中分离出的加兰他敏的二氢衍生物。Lycoramine 是一种有效的乙酰胆碱酯酶 (AChE) 抑制剂。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> 疼痛
• 靶点:

  AChE[1]

• 参考文献:

  [1]. Yuan Y, et, al. Online acetylcholinesterase inhibition evaluation by high-performance liquid chromatography-mass spectrometry hyphenated with an immobilized enzyme reactor. J Chromatogr A. 2020 Jan 4; 1609:460506.

  [2]. IRWIN RL, et, al. Cholinesterase inhibition by galanthamine and lycoramine. Biochem Pharmacol. 1960 May; 3:147-8.