HSP27 inhibitor J2

• 常用名: HSP27 inhibitor J2
• 英文名: HSP27 inhibitor J2
• CAS号: 2133499-85-9
• 分子量: 264.30
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₃H₁₂O₄S
• 熔点: N/A
• 闪点: N/A

HSP27 inhibitor J2用途

HSP27 inhibitor J2 (J2) 是一种 HSP27 抑制剂,其显著诱导异常 HSP27 二聚体形成并抑制 HSP27 巨聚合物的产生,从而具有抑制 HSP27 的伴侣功能和降低其细胞保护功能的作用。HSP27 inhibitor J2 (J2) 显著增强 17-AAG 的抗增殖活性,并对顺铂诱导的肺癌细胞生长抑制具有敏感性。

HSP27 inhibitor J2名称

• 英文名: HSP27 inhibitor J2

HSP27 inhibitor J2生物活性

• 描述: HSP27 inhibitor J2 (J2) 是一种 HSP27 抑制剂,其显著诱导异常 HSP27 二聚体形成并抑制 HSP27 巨聚合物的产生,从而具有抑制 HSP27 的伴侣功能和降低其细胞保护功能的作用。HSP27 inhibitor J2 (J2) 显著增强 17-AAG 的抗增殖活性,并对顺铂诱导的肺癌细胞生长抑制具有敏感性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> HSP
  信号通路 >> 细胞周期/DNA损伤 >> HSP
• 靶点实验:

  HSP27[2]

• 参考文献:

  [1]. Hwang SY, et al. Synthesis and biological effect of chrom-4-one derivatives as functional inhibitors of heat shockprotein 27. Eur J Med Chem. 2017 Oct 20;139:892-900.

  [2]. Younghwa Na, et al. Methods for treating pulmonary fibrosis using chromenone derivatives.

HSP27 inhibitor J2物理化学性质

• 分子式: C₁₃H₁₂O₄S
• 分子量: 264.30
• 外观性状: 固体
• 储存条件: -20°C

HSP27 inhibitor J2靶点实验

查看更多实验

实验名称：Induction of abnormal HSP27 dimerization in human NCI-H460 cells assessed as potentia... 来源：ChEMBL 靶标：Heat shock protein beta-1 External Id：CHEMBL4133480

实验名称：Induction of abnormal HSP27 dimerization in human NCI-H460 cells assessed as potentia... 来源：ChEMBL 靶标：Heat shock protein beta-1 External Id：CHEMBL4133478

实验名称：Induction of abnormal HSP27 dimerization in human NCI-H460 cells assessed as potentia... 来源：ChEMBL 靶标：Heat shock protein beta-1 External Id：CHEMBL4133479

实验名称：Induction of apoptosis in human NCI-H460 cells assessed as early apoptotic cells at 1... 来源：ChEMBL 靶标：NCI-H460 External Id：CHEMBL4133476

实验名称：Induction of apoptosis in human NCI-H460 cells assessed as necrotic cells at 10 uM af... 来源：ChEMBL 靶标：NCI-H460 External Id：CHEMBL4133477

实验名称：Induction of abnormal HSP27 dimerization in human NCI-H460 cells assessed as potentia... 来源：ChEMBL 靶标：Heat shock protein beta-1 External Id：CHEMBL4133474

实验名称：Induction of apoptosis in human NCI-H460 cells assessed as late apoptotic cells at 10... 来源：ChEMBL 靶标：NCI-H460 External Id：CHEMBL4133475

实验名称：Induction of abnormal HSP27 dimerization in human NCI-H460 cells at 10 uM after 12 hr... 来源：ChEMBL 靶标：Heat shock protein beta-1 External Id：CHEMBL4133456

实验名称：Induction of abnormal recombinant HSP27 (unknown origin) dimerization after 3 hrs by ... 来源：ChEMBL 靶标：Heat shock protein beta-1 External Id：CHEMBL4133457

实验名称：Induction of abnormal HSP27 dimerization in human NCI-H460 cells at 10 uM co-treated ... 来源：ChEMBL 靶标：Heat shock protein beta-1 External Id：CHEMBL4133455

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