木兰花碱

• 常用名: 木兰花碱
• 英文名: Magnoflorine
• CAS号: 2141-09-5
• 分子量: 342.408
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₄NO₄+
• 熔点: 252ºC
• 闪点: N/A
• 符号: GHS07
• 信号词: Warning

木兰花碱用途

(+)-Magnoflorine (Magnoflorine) 是从 Acoruscalamus 中分到的阿朴啡生物碱,具有抗真菌活性,减少 C. albicans 生物膜的形成。具有抗氧化、抗糖尿病的作用。

木兰花碱名称

• 中文名: 碘化木兰花碱
• 英文名: (+)-magnoflorine iodide
• 中文别名: 木兰花碱 | 唐松草碱 | 玉兰碱

木兰花碱生物活性

• 描述: (+)-Magnoflorine (Magnoflorine) 是从 Acoruscalamus 中分到的阿朴啡生物碱,具有抗真菌活性,减少 C. albicans 生物膜的形成。具有抗氧化、抗糖尿病的作用。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 真菌
  研究领域 >> 代谢疾病
• 靶点实验:

  Fungal[1]

• 参考文献:

  [1]. Kim J, et al. Antifungal activity of magnoflorine against Candida strains. World J Microbiol Biotechnol. 2018 Oct 31;34(11):167.

  [2]. Haque MA, et al. Magnoflorine Enhances LPS-Activated Pro-Inflammatory Responses via MyD88-Dependent Pathways in U937 Macrophages. Planta Med. 2018 Nov;84(17):1255-1264.

木兰花碱物理化学性质

• 熔点: 252ºC
• 分子式: C₂₀H₂₄NO₄+
• 分子量: 342.408
• 精确质量: 342.169983
• PSA: 58.92000
• LogP: -1.71
• InChIKey: YLRXAIKMLINXQY-ZDUSSCGKSA-O
• SMILES: COc1ccc2c(c1O)-c1c(O)c(OC)cc3c1C(C2)[N+](C)(C)CC3
• 储存条件: 2-8C

木兰花碱毒性和生态

木兰花碱安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302 + H312 + H332
• 警示性声明: P261-P280-P301 + P312 + P330-P302 + P352 + P312-P304 + P340 + P312
• 危险品运输编码: NONH for all modes of transport
• RTECS号: HQ1777600

木兰花碱靶点实验

查看更多实验

实验名称：Antidepressant activity in SPF ICR mouse assessed as decrease in immobility duration ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5368097

实验名称：Toxicity in SPF ICR mouse assessed as body weight growth at 7 mg/kg, po via gavage ad... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5368095

实验名称：Antidepressant activity in SPF ICR mouse assessed as decrease in immobility duration ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5368096

实验名称：Cytoprotective activity against corticosterone-induced mouse PC12 cell damage assesse... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5368092

实验名称：Cytoprotective activity against corticosterone-induced mouse PC12 cells assessed as c... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5368090

实验名称：Toxicity in SPF ICR mouse assessed as body weight at 7 mg/kg, po administered via gav... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5368087

实验名称：Cytoprotective activity against corticosterone-induced mouse PC12 cells assessed as c... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5368088

实验名称：Toxicity in SPF ICR mouse assessed as body weight at 7 mg/kg, po via gavage administe... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5368086

实验名称：Antimalarial activity after 24 hrs against chloroquine-sensitive Plasmodium falciparu... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL953743

实验名称：Induction of MyoD transcriptional activity in mouse C2C12 cells expressing MyoD-respo... 来源：ChEMBL 靶标：C2C12 External Id：CHEMBL3999811

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木兰花碱英文别名

• Magflorine
• escholin
• Magnoflorine
• Aporphine alkaloid
• escholine
• (6aS)-1,11-Dihydroxy-2,10-dimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolinium
• Thalictrine
• UNII-NI8K6962K4
• THALICTRIN
• (S)-5,6,6a,7-Tetrahydro-1,11-dihydroxy-2,10-dimethoxy-6,6-dimethyl-4H-dibenzo[de,g]quinolinium
• Esholine