N-(2-羟丙基)甲基丙烯酰胺

更新时间：2024-01-05 12:15:51

N-(2-羟丙基)甲基丙烯酰胺结构式	常用名	N-(2-羟丙基)甲基丙烯酰胺	英文名	N-(2-HYDROXYPROPYL)METHACRYLAMIDE
	CAS号	21442-01-3	分子量	143.18400
	密度	1.002g/cm3	沸点	321.2ºC at 760mmHg
	分子式	C₇H₁₃NO₂	熔点	70 °C
	MSDS	中文版美版	闪点	148.1ºC

N-(2-羟丙基)甲基丙烯酰胺用途

N-(2-Hydroxypropyl)methacrylamide 是用于合成共聚物,在内脏利什曼病 (VL) 中可靶向性递送抗衰老的药物。

中文名	N-(2-羟丙基)甲基丙烯酰胺
英文名	n-(2-hydroxypropyl)methacrylamide
中文别名	N-(2-羟基丙基)甲基丙烯酰胺
英文别名	更多

描述	N-(2-Hydroxypropyl)methacrylamide 是用于合成共聚物,在内脏利什曼病 (VL) 中可靶向性递送抗衰老的药物。
相关类别	研究领域 >> 感染信号通路 >> 其他 >> 其他
体内研究	在5 mg/kg体重的药物当量剂量下,含有溶酶体可降解侧链的所有N-(2-羟丙基)甲基丙烯酰胺共聚物药物共轭物显示出显著的体内抗利什曼原虫活性(>99%抑制率)[1]。
参考文献	[1]. Nan A, et al. N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers for targeted delivery of 8-aminoquinoline antileishmanial drugs. J Control Release. 2001 Dec 13;77(3):233-43. [2]. Hao Tang, et al. Comb-like Poly(N-(2-hydroxypropyl) methacrylamide) Doxorubicin Conjugates: The Influence of Polymer Architecture and Composition on the Biological Properties. Chinese Journal of Polymer Science volume 36, pages1225-1238(2018).

密度	1.002g/cm3
沸点	321.2ºC at 760mmHg
熔点	70 °C
分子式	C₇H₁₃NO₂
分子量	143.18400
闪点	148.1ºC
精确质量	143.09500
PSA	49.33000
LogP	0.45040
外观性状	固体;White to Light yellow powder to crystal
蒸汽压	2.43E-05mmHg at 25°C
折射率	1.46
储存条件	0-10°C;存放于惰性气体之中;避免空气,加热

风险声明 (欧洲)	36/37/38
安全声明 (欧洲)	26-36/37/39
危险品运输编码	NONH for all modes of transport
海关编码	2924199090

异丙醇胺

78-96-6

甲基丙烯酰氯

920-46-7

~70%

N-(2-羟丙基)甲基丙烯酰胺

21442-01-3

文献：Ebbesen, Morten F.; Schaffert, David H.; Crowley, Michael L.; Oupicky, David; Howard, Kenneth A. Journal of Polymer Science, Part A: Polymer Chemistry, 2013 , vol. 51, # 23 p. 5091 - 5099

1-methacrylamid...

897017-30-0

N-(2-羟丙基)甲基丙烯酰胺

21442-01-3

文献：Macromolecules, , vol. 36, # 20 p. 7491 - 7498

(2S)-1-methacry...

675589-71-6

N-(2-羟丙基)甲基丙烯酰胺

21442-01-3

文献：Macromolecules, , vol. 36, # 20 p. 7491 - 7498

甲基丙烯酸酐

760-93-0

异丙醇胺

78-96-6

~42%

N-(2-羟丙基)甲基丙烯酰胺

21442-01-3

文献：Solovskii; Denisov; Ryadinskaya; Petukhova; Okulova Russian Journal of Applied Chemistry, 1999 , vol. 72, # 8 p. 1443 - 1449

(2S)-1-methacry...

675589-71-6

N-(2-羟丙基)甲基丙烯酰胺

21442-01-3

Lactic acid lac...

923-17-1

文献：Macromolecules, , vol. 36, # 20 p. 7491 - 7498

1-methacrylamid...

897017-30-0

L-(+)-乳酸

79-33-4

N-(2-羟丙基)甲基丙烯酰胺

21442-01-3

文献：Macromolecules, , vol. 36, # 20 p. 7491 - 7498

海关编码	2924199090
中文概述	2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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1-methacryloylamino-2-hydroxypropane