AMT盐酸盐

• 常用名: AMT盐酸盐
• 英文名: AMT hydrochloride
• CAS号: 21463-31-0
• 分子量: 166.672
• 密度: 1.31 g/cm3
• 沸点: 236.1ºC at 760 mmHg
• 分子式: C₅H₁₁ClN₂S
• 熔点: N/A
• 闪点: 96.6ºC

AMT盐酸盐用途

盐酸AMT是一种选择性诱导型NOS(iNOS)抑制剂,Ki为4.2 nM【1】。

AMT盐酸盐名称

• 中文名: AMT盐酸盐
• 英文名: 6-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine,hydrochloride

AMT盐酸盐生物活性

• 描述: 盐酸AMT是一种选择性诱导型NOS(iNOS)抑制剂,Ki为4.2 nM【1】。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 一氧化氮合酶
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Nakane M, Klinghofer V, Kuk JE, et al. Novel potent and selective inhibitors of inducible nitric oxide synthase. Mol Pharmacol. 1995;47(4):831-834.

AMT盐酸盐物理化学性质

• 密度: 1.31 g/cm3
• 沸点: 236.1ºC at 760 mmHg
• 分子式: C₅H₁₁ClN₂S
• 分子量: 166.672
• 闪点: 96.6ºC
• 精确质量: 166.033142
• PSA: 63.68000
• LogP: 1.76440
• InChIKey: HVJCRMIQAMEJNM-UHFFFAOYSA-N
• SMILES: CC1CCN=C(N)S1.Cl
• 蒸汽压: 0.0482mmHg at 25°C
• 折射率: 1.636
• 储存条件: -20°C，密闭，干燥
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:2

  3.氢键受体数量:2

  4.可旋转化学键数量:0

  5.互变异构体数量:2

  6.拓扑分子极性表面积63.7

  7.重原子数量:9

  8.表面电荷:0

  9.复杂度:111

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:1

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:2

AMT盐酸盐安全信息

• 海关编码: 2934999090

AMT盐酸盐海关

• 海关编码: 2934999090
• 中文概述: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

AMT盐酸盐靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：qHTS to identify inhibitors of the New Delhi Metallo-beta-lactamase (NDM): assay vali... 来源：NCGC External Id：adst_MBL_Abs_LOPAC_o1

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL1266185

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

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AMT盐酸盐英文别名

• 4H-1,3-Thiazin-2-amine, 5,6-dihydro-6-methyl-, hydrochloride (1:1)
• Withaferin A
• 2-amino-5,6-dihydro-6-methyl-4h-1,3-thiazine
• 6-Methyl-5,6-dihydro-4H-1,3-thiazin-2-amine hydrochloride (1:1)
• 2-Amino-6-methyl-5,6-dihydro-4H-1,3-thiazin-hydrochlorid