LmCPB-IN-1

更新时间：2026-05-26 11:32:43

LmCPB-IN-1用途

LmCPB-IN-1(化合物35)是一种有效且可逆的共价墨西哥利什曼原虫半胱氨酸蛋白酶B(LmCPB)抑制剂,pKi为9.7【1】。

英文名	LmCPB-IN-1

描述	LmCPB-IN-1(化合物35)是一种有效且可逆的共价墨西哥利什曼原虫半胱氨酸蛋白酶B(LmCPB)抑制剂,pKi为9.7【1】。
相关类别	研究领域 >> 感染信号通路 >> 代谢酶/蛋白酶 >> 组织蛋白酶
靶点实验	pKi: 9.7 (Leishmania mexicana cysteine protease B)[1]
参考文献	[1]. Jean F R Ribeiro, et al. Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor. Bioorg Med Chem. 2020 Nov 15;28(22):115743.

分子式	C₁₈H₃₀N₆O₂
分子量	362.47
InChIKey	BTSJGBRRCQOXFA-ZDUSSCGKSA-N
SMILES	CC(C)CC(NC(=O)c1cc(C(C)(C)C)nn1C)C(=O)N(C)N(C)C#N

实验名称：Selectivity index, ratio of CC50 for monkey LLC-MK2 cells assessed as reduction in ce...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4700271

实验名称：Selectivity index, ratio of CC50 for human U2OS cells assessed as reduction in cell v...
来源：ChEMBL
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实验名称：L-Cysteine reactivity in pH 7.4 phosphate buffer assessed as half life at 2.5 mM by H...
来源：ChEMBL
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实验名称：Inhibition of Leishmania mexicana CPB delta CTE mutant using Z-Phe-Arg-7-amido-4-meth...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4703665

实验名称：Glutathione reactivity in pH 7.4 phosphate buffer assessed as half life at 2.5 mM by ...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4700272

实验名称：Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylc...
来源：ChEMBL
靶标：Cruzipain
External Id：CHEMBL4703667

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来源：ChEMBL
靶标：Procathepsin L
External Id：CHEMBL4703666

实验名称：Glutathione reactivity in pH 7.4 phosphate buffer assessed as half life at 1.25 mM by...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4700277

实验名称：Inhibition of Leishmania mexicana CPB delta CTE mutant assessed as off rate constant
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4703669

实验名称：L-Cysteine reactivity in pH 7.4 phosphate buffer assessed as decay constant at 1.25 m...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4700276

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