SB269652

更新时间：2026-07-16 21:57:35

SB269652结构式	常用名	SB269652	英文名	SB269652
	CAS号	215802-15-6	分子量	426.553
	密度	1.2±0.1 g/cm3	沸点	690.6±55.0 °C at 760 mmHg
	分子式	C₂₇H₃₀N₄O	熔点	N/A
	MSDS	美版	闪点	371.5±31.5 °C

SB269652用途

SB269652是第一类药的多巴胺D2受体的变构调节剂(D2R)。

中文名	SB269652
英文名	SB269652
英文别名	更多

描述	SB269652是第一类药的多巴胺D2受体的变构调节剂(D2R)。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体信号通路 >> 神经信号通路 >> 多巴胺受体研究领域 >> 神经疾病
参考文献	[1]. Silvano E, et al. The tetrahydroisoquinoline derivative SB269,652 is an allosteric antagonist at dopamine D3 and D2 receptors. Mol Pharmacol. 2010 Nov;78(5):925-34. [2]. Lane JR, et al. A new mechanism of allostery in a G protein-coupled receptor dimer. Nat Chem Biol. 2014 Sep;10(9):745-52. [3]. Presgraves SP, et al. Involvement of dopamine D(2)/D(3) receptors and BDNF in the neuroprotective effects of S32504 and pramipexole against 1-methyl-4-phenylpyridinium in terminally differentiated SH-SY5Y cells. Exp Neurol. 2004 Nov;190(1):157-70.

描述

SB269652是第一类药的多巴胺D2受体的变构调节剂(D2R)。

相关类别

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> 神经信号通路 >> 多巴胺受体

研究领域 >> 神经疾病

参考文献

[1]. Silvano E, et al. The tetrahydroisoquinoline derivative SB269,652 is an allosteric antagonist at dopamine D3 and D2 receptors. Mol Pharmacol. 2010 Nov;78(5):925-34.

[2]. Lane JR, et al. A new mechanism of allostery in a G protein-coupled receptor dimer. Nat Chem Biol. 2014 Sep;10(9):745-52.

[3]. Presgraves SP, et al. Involvement of dopamine D(2)/D(3) receptors and BDNF in the neuroprotective effects of S32504 and pramipexole against 1-methyl-4-phenylpyridinium in terminally differentiated SH-SY5Y cells. Exp Neurol. 2004 Nov;190(1):157-70.

密度	1.2±0.1 g/cm3
沸点	690.6±55.0 °C at 760 mmHg
分子式	C₂₇H₃₀N₄O
分子量	426.553
闪点	371.5±31.5 °C
精确质量	426.241974
LogP	5.11
InChIKey	JGLGOAQPUQITLD-UHFFFAOYSA-N
SMILES	N#Cc1ccc2c(c1)CN(CCC1CCC(NC(=O)c3cc4ccccc4[nH]3)CC1)CC2
蒸汽压	0.0±2.2 mmHg at 25°C
折射率	1.662
储存条件	2-8℃

危险品运输编码	NONH for all modes of transport

实验名称：Displacement of [3H]N-methylspiperone from human D2L receptor expressed in HEK293 cel...
来源：ChEMBL
靶标：D(2) dopamine receptor
External Id：CHEMBL4053560

实验名称：Displacement of [3H]N-methylspiperone from human D3 receptor expressed in HEK293 cell...
来源：ChEMBL
靶标：D(3) dopamine receptor
External Id：CHEMBL4053561

实验名称：Agonist activity at D2 long receptor (unknown origin) expressed in CHOK1 cells assess...
来源：ChEMBL
靶标：D(2) dopamine receptor
External Id：CHEMBL4053568

实验名称：Human D2 receptor (Dopamine receptors)
来源：IUPHAR-DB
靶标：D2 receptor (Dopamine receptors) [Homo sapiens]
External Id：215_Human

实验名称：Agonist activity at D3 receptor (unknown origin) expressed in CHOK1 cells assessed as...
来源：ChEMBL
靶标：D(3) dopamine receptor
External Id：CHEMBL4053569

实验名称：Allosteric antagonist activity at D3 receptor (unknown origin) expressed in CHOK1 cel...
来源：ChEMBL
靶标：D(3) dopamine receptor
External Id：CHEMBL4053564

实验名称：Selectivity ratio of Ki for human D2 receptor to Ki for human D3 receptor
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4053562

实验名称：Antagonist activity at D2 long receptor (unknown origin) expressed in CHOK1 cells ass...
来源：ChEMBL
靶标：D(2) dopamine receptor
External Id：CHEMBL4053563

实验名称：Negative allosteric modulation of human D2LR expressed in Flp-In-CHO cells assessed a...
来源：ChEMBL
靶标：D(2) dopamine receptor
External Id：CHEMBL4309417

实验名称：Negative allosteric modulation of human D2LR expressed in Flp-In-CHO cells assessed a...
来源：ChEMBL
靶标：D(2) dopamine receptor
External Id：CHEMBL4309416

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N-{trans-4-[2-(7-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl}-1H-indole-2-carboxamide

SB269652