Anticancer agent 60

更新时间：2025-09-13 10:23:49

Anticancer agent 60用途

抗癌剂60(化合物3h)对人类HepG2细胞具有抗增殖活性(IC50=4.13μM),并在人类HepG2异种移植小鼠模型中表现出抗肿瘤功效【1】。

英文名	Anticancer agent 60

描述	抗癌剂60(化合物3h)对人类HepG2细胞具有抗增殖活性(IC50=4.13μM),并在人类HepG2异种移植小鼠模型中表现出抗肿瘤功效【1】。
相关类别	研究领域 >> 癌症信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白信号通路 >> 细胞骨架 >> 微管/微管蛋白
靶点实验	IC50: 4.13 ± 0.54 μM in HepG2, 6.06 ± 0.46 μM in Bel-7402, 15.04 ± 0.74 μM in MCF-7[1]
参考文献	[1]. Liu Y, et al. Synthesis and structure-activity relationship study of water-soluble carbazole sulfonamide derivatives as new anticancer agents. Eur J Med Chem. 2020;191:112181.

分子式	C₂₇H₃₃N₅O₄S
分子量	523.65

实验名称：Acute toxicity in Kunming mouse assessed as survival at 60 mg/kg, iv measured for 7 d...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4685563

实验名称：Acute toxicity in Kunming mouse assessed as survival at 80 mg/kg, iv measured for 7 d...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4685562

实验名称：Acute toxicity in Kunming mouse assessed as survival at 40 mg/kg, iv measured for 7 d...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4685564

实验名称：Antitumor activity against human HepG2 cells xenografted in BALB/c nude mouse assesse...
来源：ChEMBL
靶标：HepG2
External Id：CHEMBL4685567

实验名称：Acute toxicity in iv dosed Kunming mouse measured for 7 days
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4685566

实验名称：Antitumor activity against human HepG2 cells xenografted in BALB/c nude mouse assesse...
来源：ChEMBL
靶标：HepG2
External Id：CHEMBL4685569

实验名称：Antitumor activity against human HepG2 cells xenografted in BALB/c nude mouse assesse...
来源：ChEMBL
靶标：HepG2
External Id：CHEMBL4685568

实验名称：Acute toxicity in Kunming mouse assessed as survival at 100 mg/kg, iv measured for 7 ...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4685558

实验名称：Antiproliferative activity against human HepG2 cells measured after 48 hrs by SRB ass...
来源：ChEMBL
靶标：HepG2
External Id：CHEMBL4685549

实验名称：Antiproliferative activity against human MCF7 cells measured after 48 hrs by SRB assa...
来源：ChEMBL
靶标：MCF7
External Id：CHEMBL4685551

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