艾替伏辛

• 常用名: 艾替伏辛
• 英文名: Etifoxine
• CAS号: 21715-46-8
• 分子量: 300.783
• 密度: 1.2±0.1 g/cm3
• 沸点: 421.2±55.0 °C at 760 mmHg
• 分子式: C₁₇H₁₇ClN₂O
• 熔点: N/A
• 闪点: 208.5±31.5 °C

艾替伏辛用途

Etifoxine(HOE 36-801)是GABAA受体增强剂，倾向作用于含β2或β3亚基的GABAA受体。

艾替伏辛名称

• 中文名: 艾替伏辛
• 英文名: 6-chloro-N-ethyl-4-methyl-4-phenyl-3,1-benzoxazin-2-amine

艾替伏辛生物活性

• 描述: Etifoxine(HOE 36-801)是GABAA受体增强剂,倾向作用于含β2或β3亚基的GABAA受体。
• 相关类别:
  信号通路 >> 跨膜转运 >> GABA受体
  信号通路 >> 神经信号通路 >> GABA受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Verleye M, Dumas S, Heulard I, et al. Differential effects of etifoxine on anxiety-like behaviour and convulsions in BALB/cByJ and C57BL/6J mice: any relation to overexpression of central GABAA receptor beta2 subunits? Eur Neuropsychopharmacol. 2011 Jun;2

  [2]. Bourin M, Hascot M. Implication of 5-HT2 receptor subtypes in the mechanism of action of the GABAergic compound etifoxine in the four-plate test in Swiss mice. Behav Brain Res. 2010 Apr 2;208(2):352-8.

  [3]. Gee KW, Tran MB, Hogenkamp DJ, et al. Limiting activity at beta1-subunit-containing GABAA receptor subtypes reduces ataxia. J Pharmacol Exp Ther. 2010 Mar;332(3):1040-53.

  [4]. Aouad M, Charlet A, Rodeau JL, et al. Reduction and prevention of vincristine-induced neuropathic pain symptoms by the non-benzodiazepine anxiolytic etifoxine are mediated by 3alpha-reduced neurosteroids. Pain. 2009 Dec 15;147(1-3):54-9.

  [5]. Girard C, Liu S, Cadepond F, et al. Etifoxine improves peripheral nerve regeneration and functional recovery. Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20505-10.

艾替伏辛物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 421.2±55.0 °C at 760 mmHg
• 分子式: C₁₇H₁₇ClN₂O
• 分子量: 300.783
• 闪点: 208.5±31.5 °C
• 精确质量: 300.102936
• PSA: 33.62000
• LogP: 3.78
• InChIKey: IBYCYJFUEJQSMK-UHFFFAOYSA-N
• SMILES: CCN=C1Nc2ccc(Cl)cc2C(C)(c2ccccc2)O1
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.601
• 储存条件: 库房低温,通风,干燥

艾替伏辛毒性和生态

艾替伏辛安全信息

• 海关编码: 2934999090

艾替伏辛海关

• 海关编码: 2934999090
• 中文概述: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

艾替伏辛靶点实验

查看更多实验

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) measured by imaging in HR... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303810

实验名称：Choleostatic liver toxicity, either proven histopathologically or where the ratio of ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137727

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Severe hepatitis, defined as possibly life-threatening liver failure or through clini... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137728

实验名称：Chronic liver disease either proven histopathologically, or through a chonic elevatio... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137729

实验名称：Cirrhosis, proven histopathologically. Value is number of references indexed. [column... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137730

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艾替伏辛英文别名

• Etifoxine
• Etifoxina [Spanish]
• 6-Chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine
• Etifoxina [INN-Spanish]
• Etifoxinum [INN-Latin]
• Etifoxinum [Latin]
• (6-chloro-4-methyl-4-phenyl-4H-benzo[d][1,3]oxazin-2-yl)-ethyl-amine
• Etifoxin
• rac-etifoxine
• Etafenoxine
• stresam