MPEP盐酸盐

更新时间：2025-08-20 13:35:59

MPEP盐酸盐结构式	常用名	MPEP盐酸盐	英文名	MPEP (Hydrochloride)
	CAS号	219911-35-0	分子量	229.705
	密度	1.1g/cm3	沸点	336.3ºC at 760mmHg
	分子式	C₁₄H₁₂ClN	熔点	N/A
	MSDS	中文版美版	闪点	144.8ºC

MPEP盐酸盐用途

MPEP盐酸盐是非竞争性mGlu5受体拮抗剂,IC50为36 nM。

中文名	2-甲基-6-苯基乙炔基吡啶盐酸盐
英文名	2-methyl-6-(phenylethynyl)pyridine
英文别名	更多

描述	MPEP盐酸盐是非竞争性mGlu5受体拮抗剂,IC50为36 nM。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体研究领域 >> 神经疾病
参考文献	[1]. Inta, Dragos; Filipovic, Dragana; Lima-Ojeda, Juan M. et al. The mGlu5 receptor antagonist MPEP activates specific stress-related brain regions and lacks neurotoxic effects of the NMDA receptor antagonist MK-801: Significance for the use as anxiolytic/ant [2]. Chau, Peipei; Soederpalm, Bo; Ericson, Mia The mGluR5 antagonist MPEP elevates accumbal dopamine and glycine levels; interaction with strychnine-sensitive glycine receptors. Addiction Biology (2011), 16(4), 591-599. [3]. D'Souza, Manoranjan S.; Markou, Athina Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats.

描述

MPEP盐酸盐是非竞争性mGlu5受体拮抗剂,IC50为36 nM。

相关类别

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体

研究领域 >> 神经疾病

参考文献

[1]. Inta, Dragos; Filipovic, Dragana; Lima-Ojeda, Juan M. et al. The mGlu5 receptor antagonist MPEP activates specific stress-related brain regions and lacks neurotoxic effects of the NMDA receptor antagonist MK-801: Significance for the use as anxiolytic/ant

[2]. Chau, Peipei; Soederpalm, Bo; Ericson, Mia The mGluR5 antagonist MPEP elevates accumbal dopamine and glycine levels; interaction with strychnine-sensitive glycine receptors. Addiction Biology (2011), 16(4), 591-599.

[3]. D'Souza, Manoranjan S.; Markou, Athina Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats.

密度	1.1g/cm3
沸点	336.3ºC at 760mmHg
分子式	C₁₄H₁₂ClN
分子量	229.705
闪点	144.8ºC
精确质量	229.065826
PSA	12.89000
LogP	3.59180
InChIKey	PKDHDJBNEKXCBI-UHFFFAOYSA-N
SMILES	Cc1cccc(C#Cc2ccccc2)n1.Cl
外观性状	light yellow solid
蒸汽压	0.000221mmHg at 25°C
折射率	1.614
储存条件	-20℃

MPEP盐酸盐MSDS英文版

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport
WGK德国	3
海关编码	2933399090

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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